Clinical Trials Logo

Clinical Trial Summary

This study is designed to answer whether minimal invasive vessel clotting (angioembolization) or open surgery (retroperitoneal packing) is more effective for pelvic fractures with massive bleeding. Patients admitted at daytime (7am-5pm) are treated with angioembolization while patients admitted at nighttime (5pm to 7am) are treated with open surgery.


Clinical Trial Description

In patients with pelvic fracture uncontrollable bleeding is the major cause of death within the first 24h after injury. Early hemorrhage control is therefore vital for successful treatment. Nowadays, recommended techniques for hemorrhage control in pelvic fractures are retroperitoneal pelvic packing and angioembolization, dependent upon the available technical staff and resources and the condition of the patient.

Retroperitoneal pelvic packing, on the one hand, is a relatively simple method in controlling pelvic hemorrhage even with limited resources. Since 89% of pelvic fracture hemorrhage originates from venous bleeding, fracture stabilization and compressive hemostasis by packing is a reasonable approach. Angioembolization, on the other hand, has great high effectiveness with regard to bleeding control, but requires an angiography suite and technical staff. Since hemostasis of retroperitoneal venous bleeding often can be achieved by external pelvic fixation, angioembolization is required for the 11% arterial bleedings which are hard to control by packing. Even though many authors see both methods as complements, time is crucial in the multitrauma setting and the severely injured patient does not tolerate multiple interventions well. Until now good predictors for treatment choice are unavailable, and management of hemodynamically unstable pelvic fractures remains a matter of debate.

This study was designed to answer following questions:

- Is retroperitoneal pelvic packing or angiography superior with regard to in-hospital mortality, complications, required secondary procedures, or post-intervention blood loss?

- Which of these methods is the more rapid intervention in the acute setting? ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02535624
Study type Interventional
Source Uppsala University
Contact
Status Completed
Phase N/A
Start date February 2003
Completion date February 2013

See also
  Status Clinical Trial Phase
Recruiting NCT05555459 - Performance and Safety Evaluation of Inion CompressOn Screw in Foot and Ankle Surgeries. PMCF Investigation N/A
Completed NCT03147222 - Function Focused Care: Fracture Care at Home N/A
Completed NCT03506958 - Patient Satisfaction in Treatment of Non-complex Fractures and Dislocations in Hospitals vs General Practitioners
Completed NCT04426981 - Behavioral Activation in Orthopaedic Trauma Patients: A Pilot Study N/A
Recruiting NCT04389749 - Continuous Passive Motion Following Fixation of Pelvic and Knee Fractures N/A
Recruiting NCT05068180 - Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients Phase 4
Recruiting NCT05594199 - Feasibility of a Virtual Smoking Cessation Program N/A
Completed NCT04514601 - A Quality Improvement Project to Assess and Refine the Handover Process at Morning Trauma Meetings
Completed NCT05138640 - Bone Strength and Physical Activity in Patients With a Recent Clinical Fracture
Completed NCT02272972 - Performance Improvement Program on Imaging II
Completed NCT04215315 - Fracture In Preterm Infants Study (FIPIN Study)
Completed NCT03219125 - Bone Marrow Adiposity and Fragility Fractures in Postmenopausal Women
Terminated NCT05655130 - Distal Radius Steroid Phase 1
Completed NCT04151732 - Factors Associated With Future Fractures in Middle-aged Men and Women
Completed NCT02714257 - Working to Increase Stability Through Exercise N/A
Completed NCT02428244 - Let's STOP Now Trial: Smoking in Trauma Orthopaedic Patients N/A
Recruiting NCT04501510 - Ultrasonography in Fracture Management
Completed NCT03852095 - Single Time Management Diseases in Pediatric Traumatology
Completed NCT04440631 - Gut Microbiome of Patients Undergoing Antibiotic Therapy for Orthopedic Device-related Infection
Completed NCT03370900 - Learning Retention in Radiograph Interpretation N/A