Mixed Tree Nut Food Challenges

Status Enrolling by invitation

Clinical Trial Summary

The purpose of this prospective study is twofold: 1) to establish oral tolerance to selected tree nuts and to examine potential predictors of oral tolerance and 2) to determine the usefulness of mixed tree nut allergen food challenges in more efficiently defining tree nut allergy and oral tolerance.

Clinical Trial Description

To evaluate the absence of tree nuts (TN) allergy, referred patients from one of the Arkansas Children's Hospital (ACH) Allergy Clinic physicians with current serum immunoglobulin E (IgE) to TNs that meet eligibility criteria will be invited to undergo a series of open mixed TN food challenges.

A questionnaire pertaining to their TN allergy will be administered

A brief physical exam will be performed.

Skin prick tests using selected nut allergen extracts along with a positive (histamine) and a negative (salt-water) control will be performed at the first oral food challenge visit.

Each food challenges will be performed to 1 to 3 TNs.

Two telephone follow-up phone calls will evaluate inclusion/exclusion of tree nuts in the diet post food challenge. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02070263
Study type	Observational
Source	Arkansas Children's Hospital Research Institute
Contact
Status	Enrolling by invitation
Phase
Start date	April 2009
Completion date	December 2020

View Details

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