Focal Epilepsy Clinical Trial
Unlike the first generation antiepileptic medications, newer drugs for epilepsy such as
levetiracetam are reported to have less adverse effect in children but not many studies have
systematically reviewed the subject. This study aims to prospectively evaluate the effect of
levetiracetam on neurocognition, behavioral issues and quality of life, as well as its
seizure control efficacy and other adverse events in pediatric epilepsy patients, in
comparison to carbamazepine, one of the classic antiepileptic medication, widely prescribed
for both partial and generalized seizures, despite its well known side effects.
This multicenter, open-label, parallel-group trial is expected to enroll 130 patients from
age 4 to 16 woh will be randomized into two groups, which will be prescribed with
levetiracetam or carbamazepine. Series of neuropsychological assessment and behavioral and
life evaluations of the patients will be performed at baseline period and after the 52 weeks
of study period.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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