Fluid Response Clinical Trial
Official title:
Pulse Pressure Variations as Index of Preload Dependency During Thoracic Surgery
Background: calculation of the pulse pressure variation (PPV) has repeatedly been shown to
be a reliable predictor of fluid responsiveness in mechanically ventilated patients. But PPV
measurement has not been yet validated in thoracic surgery during one-lung ventilation. The
modifications of intrathoracic pressure induced by one-lung ventilation may altered the
capabilities of PPV to predict fluid responsiveness.This study was designed to assess the
ability of PPV predict fluid responsiveness during one-lung ventilation in thoracic surgery.
Methods: a prospective observational study. Thirty five patients undergoing a pulmonary
resection (lobectomy or pneumonectomy) will be included to achieve around one hundred fluid
challenges with a 250 milliliters colloid solution in response to hemodynamic
instability.Hemodynamic instability is defined as a decrease by 20 % of artery pressure from
baseline and/or an increase by 20% heart rate from baseline. Fluid responsiveness is defined
as an increase in stroke volume index (SVI)>10% (measured with oesophageal doppler). PPV
will be calculated from recorded artery pressure curve (PPVref) before and after each fluid
challenge. An automated measurement of PPV proposed by the monitor Intelview (Philips) will
be recorded simultaneously before and after each fluid challenge.
Statistical analysis: receiver operating characteristic curve will be used to assess the PPV
capability to predict fluid responsiveness. Correlation analysis will be achieved using a
Pearson test or Spearman's rho test when necessary. Continuous data will compared using a
Student t test or a Mann-Whitney test when necessary.
- pulse pressure variation
- preload dependency
- one-lung ventilation
- thoracic surgery
;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03921125 -
Pleth Variability Index for Directed Fluid Optimization in Donors in Living Donor Liver Transplantation
|