Clinical Trials Logo

Clinical Trial Summary

Pathophysiology of perioperative fluid management in patients undergoing emergency laparotomy.


Clinical Trial Description

In critically ill patients and patients undergoing major surgery, the combination of internal fluid shifts and fluid retention resulting in extravascular fluid accumulation and postoperative organ dysfunctions, complicates perioperative fluid management and influences patient outcome. Changes in extravascular volume after surgery have been much debated, studies in major surgery suggest that extracellular volume expansion may correlate with intraoperative fluid administration, while other studies show the intravascular volume to be decreased after surgery. Difficulty in obtaining accurate measurements of the fluid phases is recognized and despite years of research, perioperative extravascular volume changes have not been clarified in acute high-risk abdominal (AHA) surgery. It is essential to be able to identify and characterize the transition from necessary fluid resuscitation to harmful fluid volume accumulation, intra- as well as extravascular. The present study seeks to investigate the perioperative fluid status and fluid shifts in patients undergoing AHA surgery, specifically focusing on intra- versus extra-vascular fluid status in patients with intestinal obstruction versus intestinal perforation. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03997721
Study type Observational [Patient Registry]
Source Copenhagen University Hospital, Hvidovre
Contact
Status Completed
Phase
Start date May 23, 2019
Completion date May 1, 2021

See also
  Status Clinical Trial Phase
Completed NCT04095143 - Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury
Terminated NCT03335124 - The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock Phase 4
Completed NCT05070819 - Atrial Natriuretic Peptide in Assessing Fluid Status N/A
Withdrawn NCT04870073 - Retrograde Autologous Priming and Mannitol for Reducing Hemodilution in Cardiac Surgery Phase 3
Recruiting NCT02989051 - Fluid Restriction Keeps Children Dry Phase 2/Phase 3
Completed NCT00852514 - The Optimization of Blood Pressure and Fluid Status Control With Eight-Polar Bioelectrical Impedance Analysis Phase 4
Completed NCT00517127 - Crystalloids Versus Colloids During Surgery Phase 4
Not yet recruiting NCT05983549 - Neutral Versus Liberal fLuId In Traumatic Brain Injury: a Randomised Controlled Trial N/A
Completed NCT03929471 - Target Weight Correction and Vascular Stiffness in Hemodialysis Patients N/A
Recruiting NCT06071026 - Hemodynamic Effects of Variations in Net Ultrafiltration Rate During Continuous Renal Replacement Therapy. N/A
Completed NCT02903316 - Predicting Fluid Responsiveness in on Pump Coronary Artery Bypass Graft Using Extra Systoles N/A
Terminated NCT02458157 - Forced Fluid Removal in High Risk Acute Kidney Injury Phase 4
Completed NCT02325856 - Application of Bioimpedance Spectroscopy in Taiwan Dialysis Patients N/A
Completed NCT01628731 - Furosemide Versus Ethacrynic Acid in Children With Congenital Heart Disease Phase 3
Not yet recruiting NCT05647200 - Optimization of Prime Fluid Strategy to Preserve Microcirculatory Perfusion During Cardiac Surgery With Cardiopulmonary Bypass, Part II N/A
Completed NCT03768752 - Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients
Terminated NCT03553394 - Effects of Restrictive Fluid Strategy on Postoperative Oliguric Pancreatic Surgery Patients N/A
Completed NCT06097923 - Implementation of Fluid Strategies Using Real-time Bioelectrical Analyzer in Surgical Intensive Care Unit (SICU) N/A
Recruiting NCT04215692 - Lung Ultrasound-guided Fluid Therapy in Pediatric Intensive Care Unit Patients N/A
Not yet recruiting NCT03322410 - Hydratation Status at Initiation of Peritoneal Dialysis: Study of the Role of Peritoneal Permeability N/A