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TOnicity of Perioperative Maintenance SoluTions — TOPMAST-1  

Fluid Overload Clinical Trial

Official title:
TOnicity of Perioperative Maintenance SoluTions - Part 1: Thoracic Surgery

Clinical Trial Summary

Prospective randomized double blind phase IV trial studying the efficacy and safety of the tonicity of two different perioperative maintenance solutions: an isotonic solution containing NaCl 0.9 in glucose 5% with an added 40 mmol/L of potassium or a commercially available premixed solution (Glucion 5%) containing a.o. 54 mmol/L of sodium and 26 mmol/L of potassium. Both solutions are administered at 27 mL/kg of ideal body weight, as recommended by current guidelines (NICE 174) and both solutions are widely used in daily clinical practice. The primary hypothesis is that isotonic maintenance solutions lead to more fluid retention than hypotonic fluids. Metabolism of both solutions is assessed by sequential analysis of urine and serum and clinical parameters.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03080831
Study type Interventional
Source University Hospital, Antwerp
Contact
Status Completed
Phase Phase 4
Start date March 9, 2017
Completion date July 15, 2018
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