New Cross-linked Hyaluronan Gel to Prevent Adhesion After USG-MVA: RCT

First Trimester Abortion Clinical Trial

Official title:
The Efficacy and Safety of a New Cross-linked Hyaluronan Gel to Prevent Adhesion After Ultrasound-guided Manual Vacuum Aspiration (USG-MVA): A Prospective Randomized Controlled Trial

Status Recruiting

Clinical Trial Summary

The objective of this prospective, randomized controlled study was to evaluate the effectiveness of this NCH gel in the prevention of IUA development as assessed by hysteroscopy after USG-MVA, in the treatment for first-trimester miscarriage. - To study the severity and extent of the IUA as assessed by the AFS and ESGE adhesion score in both groups of patients. - To examine the rate of complications or side effects with the NCH gel. - To assess the subsequent menstrual history and reproductive outcome in both groups of patients.

Clinical Trial Description

There is limited data to evaluate the incidence of IUA after using this NCH gel in patients undergoing surgical evacuation via USG-MVA for the treatment of first-trimester miscarriage. Previous RCT showed a significant reduction in IUA with the use of NCH gel, with IUA detected in only 9.5% of patients with NCH gel applied compared to 24.1% in the control group. However, the group did not involve patients undergoing surgical evacuation by USG-MVA. Therefore, the objective of this prospective, randomized controlled study was to evaluate the effectiveness of this NCH gel in the prevention of IUA development as assessed by hysteroscopy after USG-MVA, in the treatment of first-trimester miscarriage. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05360186
Study type	Interventional
Source	Chinese University of Hong Kong
Contact	Elaine NG
Phone	35052745
Email	elaineng@cuhk.edu.hk
Status	Recruiting
Phase	N/A
Start date	June 14, 2022
Completion date	May 15, 2026

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