Fetal Growth Restriction Clinical Trial
Official title:
A Cohort for Severe Placental Fetal Growth Restriction (CoSFGR)
Through multicenter study, the investigators aim to refine the process for precise prenatal diagnosis of fetal growth restriction (FGR), establish a cohort for severe maternal vascular malperfusion (MVM)-FGR, and conduct follow-up study to identify prognostic factors associated with both short-term and long-term outcomes.
Status | Recruiting |
Enrollment | 500 |
Est. completion date | December 30, 2025 |
Est. primary completion date | December 30, 2025 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 45 Years |
Eligibility | Inclusion Criteria: 1. Singleton pregnancy 2. Estimated fetal weight (EFW) or abdominal circumference (AC) < 3rd; or EFW or AC < 10th, combined with abnormal doppler, including uterine artery pulsatility index(UtA PI) >95th percentile, umbilical artery pulsatility index(UA PI) >95th percentile; or umbilical artery absent end-diastolic flow (UA-AEDF) or umbilical artery reversed end-diastolic flow(UA-REDF). 3. provision of signed written informed consent. Exclusion Criteria: 1. Fetus with congenital anomalies; 2. fetus with suspected chromosomal or single gene disorders; 3. fetus with confirmed intrauterine infection (CMV, syphilis and etc.); |
Country | Name | City | State |
---|---|---|---|
China | Shanghai First Maternity and Infant Hospital | Shanghai | Shanghai |
Lead Sponsor | Collaborator |
---|---|
Shanghai First Maternity and Infant Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Distribution of etiology in severe FGR fetuses | genetic, maternal or placenta | during the pregnancy, up to an average gestational age of 40 weeks | |
Primary | Incidence of perinatal death of MVM-FGR | Incidence of intrauterine Fetal death (IUFD) or neonatal death | death during the pregnancy (average gestational age of 40 weeks), or death in 28 days after birth | |
Secondary | Gestational age at birth | Gestational age at birth | the day at birth | |
Secondary | Neonatal morbidities | including bronchopulmonary dysplasia, necrotizing enterocolitis,hypoxic ischemic encephalopathy and etc. | pregnancy-born after 28 days | |
Secondary | birthweight | birthweight of the neonate | the day at birth | |
Secondary | incidence of abnormal neurodevelopment | incidence of any abnormal neurodevelopment diagnosed by doctor. | 2 years after birth |
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT05934318 -
L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE)
|
N/A | |
Recruiting |
NCT05601375 -
Speckle Tracking Echocardiography in Infants, Prenatally and Postnatally
|
||
Recruiting |
NCT03662178 -
Investigating the Structured Use of Ultrasound Scanning for Fetal Growth
|
||
Completed |
NCT05059093 -
Developing and Testing AI Models for Fetal Biometry and Amniotic Volume Assessment in Fetal Ultrasound Scans.
|
||
Completed |
NCT03067298 -
Prediction of Preeclampsia and Other Pregnancy Complications Following Combined Iterative Screening
|
||
Recruiting |
NCT01981824 -
Prediction of Growth Restricted Fetuses Using Femur Length to Mid-thigh Circumference Ratio: A Case-control Study
|
N/A | |
Recruiting |
NCT04215107 -
Fetal Distribution of Feto-placental Blood Flow Related to Placental Nutrient Transport and Maternal Food Intake
|
N/A | |
Completed |
NCT02189148 -
First-trimester Prediction of Preeclampsia
|
||
Terminated |
NCT04084990 -
Sleep Apnea and Fetal Growth Restriction
|
Phase 3 | |
Recruiting |
NCT04051567 -
Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies
|
Phase 4 | |
Recruiting |
NCT04394611 -
Metals and in Fetal Growth Restriction
|
||
Completed |
NCT01369940 -
The NICHD Fetal Growth Study: Twin Gestations
|
N/A | |
Not yet recruiting |
NCT03121196 -
Social Deprivation and Pregnancy
|
N/A | |
Recruiting |
NCT03177824 -
Sildenafil Citrate for Treatment of Growth-restricted Fetuses
|
Phase 3 | |
Completed |
NCT02379832 -
Pre-Eclampsia And Growth Restriction: a Longitudinal Study
|
||
Completed |
NCT02379494 -
First Trimester Prediction of Preeclampsia and Fetal Growth Restriction
|
N/A | |
Completed |
NCT03046355 -
Timing of Delivery in Fetal Growth Restriction of Uncomplicated Women
|
N/A | |
Not yet recruiting |
NCT05674487 -
Prostaglandins Versus Trans-cervical Balloon for Induction of Labor in Fetal Growth Restriction (PROBIN)
|
N/A | |
Not yet recruiting |
NCT05848869 -
Prostaglandins Versus Trans-cervical Balloon for Induction of Labor in Fetal Growth Restriction
|
N/A | |
Recruiting |
NCT04438668 -
Evaluation of the Safety and Performance of Centaflow
|
N/A |