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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT04840121
Other study ID # IIS - 1006
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date March 24, 2021
Est. completion date January 29, 2024

Study information

Verified date February 2024
Source Clinique Ovo
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Embryo implantation is a crucial event in the establishment of a pregnancy. Although the clinical and culture conditions to obtain a "good quality" embryo are well advanced today, endometrial receptivity remains a major barrier in assisted reproductive techniques. Once a high-quality embryo is transferred, impaired uterine receptivity is believed to be one of the major reasons behind failure of the establishment of pregnancy.


Recruitment information / eligibility

Status Completed
Enrollment 120
Est. completion date January 29, 2024
Est. primary completion date November 30, 2023
Accepts healthy volunteers No
Gender Female
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria: - Women between the ages of 18 to 40 inclusive at the time of oocyte retrieval - Prescription of a single frozen embryo transfer - substituted cycle protocol - Participant has at least 2 vitrified good quality blastocysts Exclusion Criteria: - Women undergoing fertility preservation - Stage IV severe endometriosis - Severe malformation, adenomyosis or uterine anomaly including fibroids deforming the uterine cavity = 5 cm - Positive results of screening for either participant or partner for HIV antibodies, Hepatitis B (other than surface antibodies present after vaccination) or Hepatitis C

Study Design


Related Conditions & MeSH terms


Intervention

Diagnostic Test:
AdhesioRT
AdhesioRT, a novel diagnostic genetic assay, developed by ovo R&D scientists, helps to predict the endometrial receptivity and embryo implantation.

Locations

Country Name City State
Canada Clinique Ovo Montreal Quebec

Sponsors (2)

Lead Sponsor Collaborator
Clinique Ovo Ferring Pharmaceuticals

Country where clinical trial is conducted

Canada, 

Outcome

Type Measure Description Time frame Safety issue
Primary Determination of appropriate window of implantation Comparison between standard frozen embryo transfer and personalized frozen embryo transfer using AdhesioRT to determine a successful window of implantation 14 days after embryo transfer
Secondary Rate of clinical pregnancy Blood test to determine if the embryo transfer was successful or not 14 days after embryo transfer
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