Female Infertility Due to Diminished Ovarian Reserve Clinical Trial
Official title:
Which is the Best IVF/ICSI Protocol to be Used in Poor Responders Receiving Growth Hormone as an Adjuvant Treatment ? A Prospective Randomized Study
in this study, we are trying to monitor the effect of the addition of growth hormone on the different down regulation protocols ( long, short, antagonist and microflare). The outcome will be primarily assessed by the clinical pregnancy rates.
Status | Completed |
Enrollment | 287 |
Est. completion date | January 2015 |
Est. primary completion date | January 2015 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 20 Years to 45 Years |
Eligibility |
Inclusion Criteria: ESHRE consensus 2011,At least two of the following three features must be present: - Advanced maternal age (=40 years) or any other risk factor for POR; - A previous POR (=3 oocytes with a conventional stimulation protocol); - An abnormal ovarian reserve test (i.e. AFC < 5-7 follicles or AMH < 0.5 -1.1 ng/ml). Exclusion Criteria: - female patients with causes of infertility other than poor ovarian reserve - females suffering from congenital or acquired uterine anomalies - females with focal uterine lesions - females who had previous ovarian surgeries - females with history of previous exposure to radiotherapy , or chemotherapy - females refusing to get enrolled in the study |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Egypt | private IVF medical center | Giza | Cairo |
Lead Sponsor | Collaborator |
---|---|
Woman's Health University Hospital, Egypt |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Numbers of oocytes retrieved and number of fertilized oocytes | Number of oocytes retrieved on the day of vaginal egg collection guided by trans vaginal ultrasound scan , 35 hours after hCG administration. | 2 years | No |
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