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Female Factor Infertility clinical trials

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

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NCT ID: NCT01661010 Completed - Clinical trials for Male Factor Infertility

The Clinical Study of Sex Chromosome Variants

Start date: July 30, 2012
Phase:
Study type: Observational

Purpose/Lay Summary: Background: - Chromosomes are the structures inside of each cell that carry our genetic material (genes). Certain differences in the sex chromosomes are known to cause various diseases, such as infertility, Turner syndrome, or Klinefelter syndrome. However, it is not fully understood why these differences are seen and what clinical findings may be caused with different sex chromosome variants. This study is seeking to learn more about the genetic and clinical characteristics of disorders related to the X and Y chromosomes. Objectives: - To study related medical conditions in people with sex chromosome variants. Eligibility: - Patients with known sex chromosome differences may be eligible to participate. - Healthy volunteers age 18 - 55 Design: - Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected. - This study will last about 5 days. Participants will have a variety of endocrine and other tests. They will provide blood, urine, and semen samples for these tests. - Imaging studies of the heart and abdomen will be performed. These tests may include ultrasounds and magnetic resonance imaging. - Participants will also have their vision and hearing checked. - Healthy volunteers with have a single day visit for a medical history, physical exam, and blood and skin samples. - Treatment will not be provided as part of this study. - Compensation is offered.