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Feeding and Eating Disorders clinical trials

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NCT ID: NCT03968705 Active, not recruiting - Clinical trials for Feeding and Eating Disorders

Longstanding Eating Disorders and Personality Disorders

Start date: January 1998
Phase:
Study type: Observational

Background Eating disorders rank among the ten leading causes of disability among young women, and anorexia nervosa has the highest mortality rate of all mental disorders. Follow-up studies have shown that 20-30 % of patients with eating disorders develop longstanding symptoms, seriously impairing their daily and represents a public health concern. There are very few studies on the course of these patients. Several studies have demonstrated comorbidity between eating disorders and personality disorders. Among patients with eating disorders, the reported frequencies of personality disorders vary from 27% to 77%. Most of the studies are cross-sectional designs, thus unable to catch trends or changes over time. There is a need for prospective longitudinal studies of adult patients using structured diagnostic interviews both for eating disorders and personality disorders. At Modum Bad, a Norwegian psychiatric hospital, the investigators have conducted a follow-up study of patients with longstanding eating disorder 1-, 2- and 5-years after treatment. The aim of the present project is to follow-up the patients additional 17-years after treatment. Objective Investigate the 17-years course and outcome of adult patients with severe and longstanding eating disorders with regard to eating disorder-related symptoms, general symptoms and personality disorders in addition to examining whether personality disorders and sexual abuse in childhood can predict the course and outcome. Method Examining patients 17-years after treatment with standardized interviews and questionnaires.

NCT ID: NCT03966157 Completed - Feeding Disorders Clinical Trials

Nasal Bridles and Repeat Endoscopic Procedures for Endoscopic Nasoenteric Tubes

Start date: June 19, 2019
Phase: N/A
Study type: Interventional

In critically ill patients, nutrition is a major part of healing and recovery. In patients unable to tolerate oral feeding, nasoenteric tube feeding (a tube placed from the nose to the stomach or small intestine) provides a safe alternative for feeding. Some patients require these tubes to be placed endoscopically due to numerous patient factors including difficult anatomy, need for post-gastric feeding, among others). In patients that require endoscopically placed tubes, there is risk of perforation, infection, bleeding, aspiration, and rarely even death. In patients that have recurrent dislodgement of endoscopically placed tubes, the need for repeat endoscopy increases patient exposure to these risks. Traditional securing mechanism with adhesive tape to reduce dislodgment often fail in critically ill patients requiring patients to have repeat endoscopies to replace nasoenteric feeding tubes and subjects patients potentially to increased cumulative risks associated with each endoscopy. The investigators propose to collect data for one year, the investigators will prospectively follow via chart review endoscopically placed naso-enteric tubes placed with a Standard AMT Bridle securement device and assess if there is a reduction in accidental tube removal requiring replacement endoscopically.

NCT ID: NCT03948217 Terminated - Anorexia Nervosa Clinical Trials

The Effects of Artificial Lighting on Affective and Core Symptoms of Eating Disorder

METROPOLIS
Start date: May 1, 2018
Phase: N/A
Study type: Interventional

The primary objective of this pilot study is to explore the effect of artificial lighting on affective symptoms, and the secondary aim is to explore the effect of artificial lighting on core symptoms of eating disorders (ED). Several lines of evidence, albeit from hypothesis generation studies, suggest that artificial lighting may have a positive effect on well-being, mental health and affective symptoms in ED. The rationale of this study is to investigate the effects of artificial lighting on affective symptoms and cores symptoms of ED in inpatients undergoing weight restoration/treatment for ED. Study design: Single-blind, controlled, pilot intervention study with circadian light (CL) comparing two CL regimens effects on mood symptoms. Planned number of subjects: 16 patients with a ICD-10 diagnosis of Anorexia Nervosa, that completes exposure to at least three weeks of the two different CL regimens (L1 and L2) in any order.

NCT ID: NCT03946540 Active, not recruiting - Anorexia Nervosa Clinical Trials

Longitudinal Follow Up of Eating Disorder Treatment

L-FED
Start date: July 14, 2019
Phase:
Study type: Observational

The research proposed here seeks to delineate the outcomes of people who have received treatment for an eating disorder at a specialist eating disorder service in childhood or adolescence (hereafter 'former patients'). This will inform our understanding of the maintenance of treatment effects beyond initial trial follow-ups, and together with data collected during treatment will allow for identification of factors predicting chronicity which will inform further treatment development.

NCT ID: NCT03946111 Terminated - Obesity Clinical Trials

Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Medication Change for Non-Responders

Start date: August 7, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

This study will test the relative efficacy and effectiveness of the combination of naltrexone and bupropion (NB) medication as a treatment for binge-eating disorder (BED) in patients with obesity. This is a controlled test of whether, amongst non-responders to acute treatments, NB medication results in superior outcomes compared with placebo.

NCT ID: NCT03942874 Completed - Bulimia Nervosa Clinical Trials

Development and Initial Tests of Reward Re-Training: A Novel Treatment For Reward Dysfunction

Recharge
Start date: April 24, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to test a novel treatment for binge eating that will be compared to a waitlist control group. The investigators are seeking to target factors that might influence binge eating by increasing reward in non-food life domains. The treatment is weekly for 10 weeks and will take place at Drexel University in Philadelphia.

NCT ID: NCT03934697 Completed - Anorexia Nervosa Clinical Trials

Imaginal Exposure II Study: In-Vivo

In-vivo IE II
Start date: May 1, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to test if imaginal exposure therapy can decrease symptoms of eating disorders and anxiety.

NCT ID: NCT03926052 Active, not recruiting - Obesity Clinical Trials

Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Maintenance Treatment

Start date: August 7, 2019
Phase: Phase 3
Study type: Interventional

This study will test the effectiveness of lisdexamfetamine (LDX) medication as a maintenance therapy for the treatment of binge-eating disorder (BED) in patients with obesity. This is a controlled test of whether, amongst responders to acute treatments, LDX medication results in superior maintenance and longer-term outcomes compared with placebo.

NCT ID: NCT03924193 Completed - Obesity Clinical Trials

Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Acute Treatment

Start date: March 25, 2019
Phase: Phase 3
Study type: Interventional

Brief Summary: This study will compare the effectiveness of cognitive behavioral therapy (CBT), lisdexamfetamine (LDX), and the combination of CBT and LDX for the treatment of binge-eating disorder in patients with obesity. This is an acute treatment comparing CBT or LDX alone or in combination.

NCT ID: NCT03921632 Completed - Eating Disorder Clinical Trials

Impact of an Oral Health Intervention

Start date: January 1, 2016
Phase: N/A
Study type: Interventional

This pilot study will assess the effectiveness of an original oral health education program on affecting the behaviors of patients diagnosed with eating disorders.