Fatigue Clinical Trial
Official title:
Behavioral and Neural Representations of Subjective Effort Cost
The goal of this proposal is to understand the common and distinct behavioral and neural representations of subjective effort valuation, and how these representations are influenced by fatigue and changes in motivation. It is hypothesized that the brain will use overlapping and distinct neural circuits to represent cognitive and physical effort value, and that fatigue and enhanced motivation will influence the subjective value of effort.
Status | Recruiting |
Enrollment | 185 |
Est. completion date | December 31, 2024 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: - Right-handed - Age between 18 and 35 years old - Male or female - Any ethnicity Exclusion Criteria: Individuals with a history of any of the following will be excluded from the study: - Neurological problems such as stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease (self- report) - Diagnosed history of severe psychiatric disease such as depression, schizophrenia (self-report) - Metal in the head or eyes - If they are pregnant or suspect that you may be pregnant - If they experience discomfort from the MRI scan, such as severe claustrophobia or excessive heating of tattoos |
Country | Name | City | State |
---|---|---|---|
United States | Kennedy Krieger Institute | Baltimore | Maryland |
Lead Sponsor | Collaborator |
---|---|
Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | National Institute of Mental Health (NIMH) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Mean of cognitive subjective effort parameters (from behavioral choice data) | Choice data will be fit to a model of the form u(x) = x^rho. The parameter rho is indicative of individuals' subjective preferences for effort. We will test if participants cognitive subjective effort parameters will be significantly different than zero. Effort levels will be expressed as a percentage of each individual's maximum exertion capacity. This will ensure that comparisons can be made between participants. | 1 day | |
Primary | Differences between cognitive subjective effort parameters before and after fatigue (from behavioral choice data) | Choice data will be fit to a model of the form u(x) = x^rho. The parameter rho is indicative of individuals' subjective preferences for effort. We will test if participants cognitive subjective effort parameters will be significantly different when comparing parameters extracted from pre-fatigue and post-fatigue choices. Effort levels will be expressed as a percentage of each individual's maximum exertion capacity. This will ensure that comparisons can be made between participants. | 1 day | |
Primary | Mean of physical subjective effort parameters (from behavioral choice data) | Choice data will be fit to a model of the form u(x) = x^rho. The parameter rho is indicative of individuals' subjective preferences for effort. We will test if participants physical subjective effort parameters will be significantly different than zero. Effort levels will be expressed as a percentage of each individual's maximum exertion capacity. This will ensure that comparisons can be made between participants. | 1 days | |
Primary | Differences between physical subjective effort parameters before and after fatigue (from behavioral choice data) | Choice data will be fit to a model of the form u(x) = x^rho. The parameter rho is indicative of individuals' subjective preferences for effort. We will test if participants physical subjective effort parameters will be significantly different when comparing parameters extracted from pre-fatigue and post-fatigue choices. Effort levels will be expressed as a percentage of each individual's maximum exertion capacity. This will ensure that comparisons can be made between participants. | 1 day | |
Primary | Difference between cognitive effort cost parameters between the low and high reward stimuli | Choice data will be fit to a model of the form u(x) = x^rho. The parameter rho is indicative of individuals' subjective preferences for effort. We will test if participants subjective effort parameters will be significantly different when comparing parameters extracted from low and high reward stimuli trials. Effort levels will be expressed as a percentage of each individual's maximum exertion capacity. This will ensure that comparisons can be made between participants. | 1 day | |
Primary | Difference between physical effort cost parameters between the low and high reward stimuli | Choice data will be fit to a model of the form u(x) = x^rho. The parameter rho is indicative of individuals' subjective preferences for effort. We will test if participants subjective effort parameters will be significantly different when comparing parameters extracted from low and high reward stimuli trials. Effort levels will be expressed as a percentage of each individual's maximum exertion capacity. This will ensure that comparisons can be made between participants. | 1 day | |
Primary | Regions of the brain encoding cognitive effort | We will use a general linear model to examine brain activity that is positively and negatively correlated with chosen cognitive effort value. | 1 day | |
Primary | Regions of the brain encoding physical effort | We will use a general linear model to examine brain activity that is positively and negatively correlated with chosen physical effort value. | 1 day | |
Primary | Regions of the brain encoding changes cognitive effort value following cognitive fatigue | We will use a general linear model to examine brain activity that is positively and negatively correlated with fatigue-induced changes in cognitive effort value. | 1 day | |
Primary | Regions of the brain encoding changes physical effort value following physical fatigue | We will use a general linear model to examine brain activity that is positively and negatively correlated with fatigue-induced changes in physical effort value. | 1 day | |
Primary | Regions of the brain encoding differences in cognitive effort value resulting from reward-induced changes in motivation | We will use a general linear model to examine brain activity that is positively and negatively correlated with motivation-induced changes in cognitive effort value. | 1 day | |
Primary | Regions of the brain encoding differences in physical effort value resulting from reward-induced changes in motivation | We will use a general linear model to examine brain activity that is positively and negatively correlated with motivation-induced changes in physical effort value. | 1 day |
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