Fatigue Clinical Trial
Muscle strength and endurance are important indexes of fitness. The muscle strength is the
most important single predict factor of functional ability in aged frail individuals.
Frailty related muscle weakness and fatigue are adapted from the pre-frail stage. Finding
the contributions of the central and the peripheral factors to the deficits of muscle
fitness and developing an effective muscle fitness training program for pre-frail
individuals are very important.
The muscle weakness and fatigue can be categorized into peripheral or central causes. The
central fatigue and voluntary activation failure originate from the decrease in motivation
or the reduction of the conduction within corticospinal tracts. Long term activation failure
and central fatigue will cause disuse of muscle and result in peripheral weakness and
peripheral fatigue. Studies found the selective type II fiber atrophy in aged people and
this finding was different from the type I atrophy in conventional immobilization models. It
is possible that the activation failure leads to the recruitment failure of high threshold
type II fibers at the pre-frail stage. Quantifying the weighting of central versus
peripheral factors contributing to the exercise limitation in pre-frail people is important.
Most of the conventional strength and endurance training programs are based on the
researches of young groups. These programs are not able to prevent people become frail. It
is possibly that, due to the limitation of central fatigue, the pre-frail individuals stop
exercise before the effective intensity being achieved. Almost no training program has been
design for enhancing the voluntary activation level and relief the central fatigue. Seeking
an appropriate training program to enhance central activation at the pre-frail stage is very
important for preventing people become frail.
Previous studies have shown that increasing afferent input by peripheral electrical
stimulation (ES) at sensory threshold enhanced the plasticity of contralateral primary
sensory cortex, the excitability of corticospinal tracts, and the functional performance in
young adults. ES, which is easy to quantify the dose of afferent input, is a feasible method
to be used in training. Combining afferent input with strength training might be able to
overcome the central activation failure and help recruit high threshold motor unit in
pre-frail individuals.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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