Evaluation and Diagnosis of People With Pain and Fatigue Syndromes

Fatigue Clinical Trial

Official title:

Evaluation and Diagnosis of Potential Research Subjects With Pain and Fatigue Syndromes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00677157
• Other study ID #: 080132
• Secondary ID: 08-NR-0132
• Status: Completed
• Start date: May 23, 2008
• Est. completion date: September 17, 2020

Study information

• Verified date: September 2020
• Source: National Institutes of Health Clinical Center (CC)
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study will examine people who have pain or fatigue symptoms with a known or unknown diagnosis to determine eligibility for other research studies. No treatment is offered under this protocol.

People 18 years of age or older with symptoms of pain and fatigue may be eligible for this study. Participants undergo standard examinations needed to diagnose or evaluate their symptoms. The results of the test are used to screen subjects for possible participation in other Nursing Institute studies. The study requires from one to three visits at NIH over 12 months for procedures that may include the following:

• Medical history, physical examination and questionnaires related to symptoms and quality of life.

• Blood tests

• Electrocardiogram

• Tender point testing. Pressure is applied to areas of the shoulder, hip, neck, chest, elbow and knee to identify tenderness.

Description:

This screening protocol is designed to facilitate patient recruitment to the National Institute of Nursing Research (NINR) clinical research studies on pain and fatigue syndromes. This protocol will also validate the newly developed Saligan Fatigue Questionnaire. Patients must meet the specific requirements of an IRB-approved research study; this protocol serves as a first step for evaluating patients for possible inclusion in a natural history or intervention protocol.

Candidates will be screened with medical history/physical examination, routine laboratory tests, and questionnaires. The physical examination may include the standardized tender point assessment as specified in the American College of Rheumatology (ACR) to diagnose fibromyalgia, measurements of pain (allodynia, hyperalgesia, and hyperpathia), edema, autonomic dysfunction (altered skin color, temperature, or sudomotor activity), and extent of musculoskeletal dysfunction. It will also assess the patients level of pain, fatigue, and quality of life by providing questionnaires for the patients to complete. When the screening is completed, patients will be informed of their options to participate in other NINR interventional or observational clinical research studies. Patients who are not eligible for these studies will be informed of alternative treatments. No treatment is offered under this protocol. Information collected in this protocol will be used to determine eligibility to other NINR protocols.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 367
• Est. completion date: September 17, 2020
• Est. primary completion date: September 17, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

• INCLUSION CRITERIA:

To be included, patients must meet all of the following:

• Are greater than or equal to 18 years of age;

• Have symptoms of pain and/or fatigue.

EXCLUSION CRITERIA:

Patients with any one of the following will be excluded:

• Inability to provide informed consent for the study;

• Are unwilling or unable to cooperate with the study procedures or travel to NIH for the procedures.

In addition to the above criteria, participants with the following conditions will be excluded from the participating in the peak exercise testing:

• Pregnant or lactating women.

• Unable to refrain from smoking at least 4 hours prior to exercise testing sessions.

• Any medical condition that limits exercise performance and/or affects participants safety during exercise. This includes diseases of the cardiovascular, pulmonary, neurological, metabolic or musculoskeletal systems such as:

• Diagnosis or history of ischemic heart disease

• Dilated or hypertrophic cardiomyopathy

• Non-idiopathic cardiomyopathy

• Uncontrolled hypertension, defined as a resting blood pressure above 140/90 mmHg

• Diagnosis or history of right or left-sided heart failure or pulmonary hypertension

• Diagnosis or history of restrictive or obstructive lung disease

• Diagnosis or history of stroke

• Uncontrolled Type I or Type II Diabetes Mellitus

• Diagnosis of chronic liver disease, chronic kidney disease, acute kidney injury or acute liver failure

• Metastatic cancer active within the previous five years

• Mitochondrial disease

• On medications that would influence aerobic capacity or treadmill performance such as beta-blockers or antiretroviral therapy

• Active substance abuse including ETOH

• Medical or psychological instability such that subjects could not reasonably be expected to fulfill the study requirements

Related Conditions & MeSH terms

• Fatigue

Locations

Country	Name	City	State
United States	National Institutes of Health Clinical Center, 9000 Rockville Pike	Bethesda	Maryland

Sponsors (1)

Lead Sponsor	Collaborator
National Institute of Nursing Research (NINR)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Eligibility for participation in NINR study	Qualification for an active NINR study.	screening visit

External Links

•   NIH Clinical Center Detailed Web Page