Fatigue Clinical Trial
Official title:
Phase II Trial of Progressive Resistance Training With Megestrol Acetate for the Treatment of Cancer-Related Weight Loss
RATIONALE: Megestrol helps improve appetite. Exercise may decrease cancer-related fatigue,
improve strength, and build up lost muscle tissue. Exercise plus megestrol may be effective
treatment for cancer-related weight loss.
PURPOSE: Phase II trial to study the effectiveness of megestrol plus exercise to improve
appetite, increase strength, gain lean body tissue, and decrease fatigue in patients who
have cancer-related weight loss.
OBJECTIVES: I. Determine the effect of megestrol and progressive resistance training on lean
body mass, total body weight, functional capacity, appetite, and fatigue in patients with
weight loss due to advanced malignancy.
OUTLINE: This is a multicenter study. Patients receive oral megestrol once daily. Patients
also begin progressive resistance training 3 days a week. Treatment/exercise continues for
12 weeks in the absence of unacceptable toxicity or progressive weight loss (greater than 5
pounds or 5% or more over first 4 study weeks).
PROJECTED ACCRUAL: A total of 46 patients will be accrued for this study within 1 year.
;
Primary Purpose: Supportive Care
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