Markers of Defective Membrane Remodelling in Scott-like Syndromes

Familial Bleeding Disorder Clinical Trial

Official title: Defect in Cell Stimulation and Unexplained hemorrhagesMarkers Related to Membrane Remodelling in the Prognosis Scott-like Syndormes

Status Terminated

Clinical Trial Summary

Purpose: Identification of the gene(s) involved in plasma membrane remodelling. Identification of the circulating markers affected by the defective membrane remodelling in a collection of families with unexplained provoked hemorrhages and evaluation of their prognosis value in the assessment of the hemostatic cellular response.Hypothesis: Scott syndrome is rare a familial disorder characterized by provoked haemorrages in homozygous-type patients due to isolated membrane remodelling deficiency. Membrane remodelling is necessary for cellular hemostatic responses.

Clinical Trial Description

n/a

Study Design

Observational Model: Family-Based, Time Perspective: Prospective

Related Conditions & MeSH terms

• Blood Coagulation Disorders
• Familial Bleeding Disorder
• Hemostatic Disorders
• Scott Syndrome
• Syndrome
• Unexplained Isolated Provoked Hemorrhages

• NCT number: NCT00617721
• Study type: Observational
• Source: University Hospital, Strasbourg, France
• Status: Terminated
• Phase: N/A
• Start date: June 2008