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Clinical Trial Summary

The purpose of this study is to compare four regimens using US FDA GMP intravenous artesunate for the treatment of uncomplicated Plasmodium falciparum malaria to identify the most effective treatment regimen as determined by rapidity of parasite clearance by microscopy.


Clinical Trial Description

To compare the efficacy and tolerability of intravenous artesunate for the initial treatment of uncomplicated Plasmodium falciparum malaria at doses that bracket anticipated clinical doses (2.4 mg/kg once daily for 3 days; or 2.4 mg/kg initially, at 12 hours on Day 0, and then daily on Day 1 and 2) and thereby establish the safest, highly efficacious dosing regimen for use in future clinical trials. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT00459615
Study type Interventional
Source Walter Reed Army Institute of Research (WRAIR)
Contact
Status Completed
Phase Phase 2
Start date April 2007
Completion date January 2008

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