Wet Macular Degeneration Study to Compare Ranibizumab or Bevacizumab to Aflibercept

Exudative Macular Degeneration Clinical Trial

Official title:
A Single Arm, Investigator Initiated Study of the Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Injection in Subjects With Exudative Age-related Macular Degeneration Previously Treated With Ranibizumab or Bevacizumab (ASSESS Study)

Status Completed

Clinical Trial Summary

This study will examine the use of Aflibercept in patients with exudative macular degeneration requiring intravitreal injections. Patients will be followed for 24 months. The follow up phase will be completed at month 36.

Clinical Trial Description

The purpose of this study is to examine the use of Aflibercept in patients who have been previously treated with Ranibizumab or Bevacizumab for exudative macular degeneration. Specifically, we will examine its effect on macular degeneration, measured by SDOCT (Spectral Domain Optical Coherence Tomography) and ETDRS (Early Treatment Diabetic Retinopathy Study) visual acuity. This will be a prospective study with patients to receive an intravitreal injection of Aflibercept at the time of treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01617148
Study type	Interventional
Source	The Cleveland Clinic
Contact
Status	Completed
Phase	Phase 4
Start date	June 2012
Completion date	December 2015

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01835067` - Intravitreal tPA and C3F8 for the Treatment of Submacular Haemorrhage as a Complication of Neovascular AMD	Phase 2/Phase 3
Completed	`NCT01674569` - Pilot Study of X-82 in Patients With Wet AMD	Phase 1/Phase 2
Recruiting	`NCT04504123` - MMP-9 Inhibition for Recalcitrant Wet AMD	Phase 2
Completed	`NCT01473251` - Analysis of Growth Factors in Patients Undergoing Lucentis or Avastin Injections for Diabetic Macular Edema and Exudative Macular Degeneration	N/A
Recruiting	`NCT05093374` - Treatment of Neovascular AMD: Artificial Intelligence in Real-world Setting	Phase 4
Completed	`NCT01535950` - Safety and Efficacy of Intravitreal LFG316 in Wet Age Related Macular Degeneration (AMD)	Phase 2
Completed	`NCT02287298` - Triple Combination Therapy of Choroidal Neovascularization in AMD, a Cost Effect and Efficient Therapeutic Treatment	N/A
Active, not recruiting	`NCT03803631` - CNV in AMD Analyzed by OCT Angiography Under IntravitreaL Eylea (COCTAEyl)