Extensive Stage Small Cell Lung Cancer Clinical Trial
Official title:
A Phase II Study of Dasatinib (NSC #732517) in Patients With Chemo-Sensitive Relapsed Small Cell Lung Cancer
This phase II trial is studying how well dasatinib works in treating patients with relapse small cell lung cancer. Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
PRIMARY OBJECTIVE I. Determine the efficacy of dasatinib in patients with relapsed small
cell lung cancer.
SECONDARY OBJECTIVE II. Determine the objective response rate (complete and partial
response) in patients treated with this drug.
III. Determine the overall survival of patients treated with this drug. IV. Determine the
toxicity of this drug in these patients.
OUTLINE:
Patients receive oral dasatinib twice daily on days 1-21. Treatment repeats every 21 days in
the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed at least every 3 months for 1
year and then every 6 months for 3 years.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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