Exercise Clinical Trial
Official title:
Exercise to Slow Cardiovascular Ageing Progression
NCT number | NCT05775484 |
Other study ID # | 2022/2667 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | May 1, 2023 |
Est. completion date | December 31, 2051 |
Verified date | May 2023 |
Source | National Heart Centre Singapore |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.
Status | Recruiting |
Enrollment | 450 |
Est. completion date | December 31, 2051 |
Est. primary completion date | December 31, 2026 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 21 Years to 100 Years |
Eligibility | Inclusion Criteria: - Age >=21 years old - Outdoor ambulant Exclusion Criteria: - Wheelchair or bed-bound - Dementia - Residing in sheltered or nursing home - Cancer - Participation in ongoing clinical trials that involve interventional drugs or devices - Aneurysms - Acute infections (in the last six months) - Uncontrolled thyrotoxicosis - Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise - Uncontrolled asthma or chronic lung disease - Restrictive lung disease |
Country | Name | City | State |
---|---|---|---|
Singapore | National Heart Centre Singapore | Singapore |
Lead Sponsor | Collaborator |
---|---|
National Heart Centre Singapore |
Singapore,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Metabolite profiles | To measure changes in serum metabolite levels among participants pre and post exercise intervention. | 12 Months | |
Primary | Cardiovascular structure and function | To measure changes in CV structure and function (diastolic function, arterial stiffness) among participants. | 12 Months |
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