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NCT05775484 Clinical Trial

Exercise to Slow Cardiovascular Ageing Progression

Exercise Clinical Trial

Official title:
Exercise to Slow Cardiovascular Ageing Progression

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05775484
Other study ID # 2022/2667
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date May 1, 2023
Est. completion date December 31, 2051

Study information
Verified date May 2023
Source National Heart Centre Singapore
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.

Description:

Participants from each stratum will be randomized to receive either an exercise program intervention or no exercise. At the start and end of study, participants will undergo cardiovascular imaging and metabolic profiling. Investigators will determine if exercise can reverse high-risk metabolic profiles and improve cardiovascular structure and function. Without clear mechanisms to explain cardiovascular ageing nor interventions known to retard cardiovascular ageing, our approach will provide much needed translational evidence to incorporate targeted interventions aimed at reducing cardiovascular disease risk in older populations.

Recruitment information / eligibility
Status Recruiting
Enrollment 450
Est. completion date December 31, 2051
Est. primary completion date December 31, 2026
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 21 Years to 100 Years
Eligibility Inclusion Criteria: - Age >=21 years old - Outdoor ambulant Exclusion Criteria: - Wheelchair or bed-bound - Dementia - Residing in sheltered or nursing home - Cancer - Participation in ongoing clinical trials that involve interventional drugs or devices - Aneurysms - Acute infections (in the last six months) - Uncontrolled thyrotoxicosis - Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise - Uncontrolled asthma or chronic lung disease - Restrictive lung disease

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Singapore National Heart Centre Singapore Singapore

Sponsors (1)
Lead Sponsor Collaborator
National Heart Centre Singapore

Country where clinical trial is conducted

Singapore, 

Outcome
Type Measure Description Time frame Safety issue
Primary Metabolite profiles To measure changes in serum metabolite levels among participants pre and post exercise intervention. 12 Months
Primary Cardiovascular structure and function To measure changes in CV structure and function (diastolic function, arterial stiffness) among participants. 12 Months
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