Resistance Training in the Fasted State

Exercise Clinical Trial

Official title:

Effects of Resistance Training Performed in the Fasted State Compared to the Fed State on Morphological and Neuromuscular Adaptations in Young Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05482750
• Other study ID #: URioGrandeESEFID
• Status: Completed
• Phase: N/A
• Start date: May 23, 2022
• Est. completion date: December 23, 2022

Study information

• Verified date: May 2023
• Source: Federal University of Rio Grande do Sul
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

It is well evidenced in the literature that fasting aerobic exercise generates a series of metabolic differences when compared to exercise performed in the fed state, including the use of fats predominantly as an energy source. Consequently, increases in adaptations to aerobic training, related to health and physical performance, are observed when sessions are performed in the fasted state. In relation to resistance training, the evidence is limited. There is a lack of data in the literature regarding the effects of fasting on resistance exercises and whether this practice may reflect in losses or improvements in morphological and neuromuscular adaptations related to resistance training. Thus, the aim of the present project is to compare the effects of resistance training performed in the fasted state compared to the fed state during 12 weeks on body composition and physical performance in young adults. Thirty-four eutrophic or overweight individuals, not engaged in regular resistance exercises, aged between 20 and 40 years, will be recruited. They will be put on a standard customized diet and will perform 2 weekly sessions of resistance exercise after overnight fasting (10 to 12 hours) or in the fed state, for 12 weeks. Before, in the middle and after this period, evaluations of body composition, muscle thickness and quality, maximum dynamic strength and maximum power will be analyzed. Comparisons will be performed using Generalized Estimating Equations (GEE), adopting the factors group (2 stratifications) and time (3 stratifications). All results will be expressed as mean and standard deviation and the accepted significance level will be 5%.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 28
• Est. completion date: December 23, 2022
• Est. primary completion date: December 23, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 19 Years to 40 Years

Eligibility

Inclusion Criteria:

• Men and women;
• Aged between 19 and 40 years;
• Body mass index (BMI) between 18 and 29.9 kg/m²;
• Not engaged in regular strength physical exercise (>1 weekly session) for the last 3 months.

Exclusion Criteria:

• Smokers;
• Use of medications and/or supplements that may influence the outcomes evaluated;
• Individuals who have a chronic disease that may prevent physical exercise.

Related Conditions & MeSH terms

• Exercise
• Fasting
• Resistance Training

Intervention

Other:
• Resistance training in the fasted state
On the first day of evaluations, the subjects will perform the basal metabolic rate (BMR) analysis, as well as familiarization with the neuromuscular tests. After the preliminary tests, the volunteers will perform the pre-intervention procedures. Assessments of body composition, muscle thickness and quality, maximum dynamic strength and maximum power will be performed. In addition, instruments related to dietary control and physical activity level will be applied. Subsequently, in a randomized manner, participants will be allocated to one of two different interventions. During the intervention (8 weeks), the adherence to the standard diet will be verified, as well as body composition, muscle thickness and quality, maximum dynamic strength and maximum power will be reassessed. After the 12 weeks of intervention, the volunteers will perform the evaluations referring to the post-intervention moment, following the same steps of the pre-intervention collections.
• Resistance training in the fed state
On the first day of evaluations, the subjects will perform the basal metabolic rate (BMR) analysis, as well as familiarization with the neuromuscular tests. After the preliminary tests, the volunteers will perform the pre-intervention procedures. Assessments of body composition, muscle thickness and quality, maximum dynamic strength and maximum power will be performed. In addition, instruments related to dietary control and physical activity level will be applied. Subsequently, in a randomized manner, participants will be allocated to one of two different interventions. During the intervention (8 weeks), the adherence to the standard diet will be verified, as well as body composition, muscle thickness and quality, maximum dynamic strength and maximum power will be reassessed. After the 12 weeks of intervention, the volunteers will perform the evaluations referring to the post-intervention moment, following the same steps of the pre-intervention collections.

Locations

Country	Name	City	State
Brazil	Escola de Educação Física, Fisioterapia e Dança - UFRGS	Porto Alegre	Rio Grande Do Sul

Sponsors (1)

Lead Sponsor	Collaborator
Federal University of Rio Grande do Sul

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Body mass	Body mass will be measured using a scale (Urano, Canoas, Brazil).	1 minute
Primary	Lean body mass	Lean body mass will be determined using the dual energy X-ray absorption (DEXA) method, using a densitometry machine (Hologic GE, Bedford, USA).	15 minutes
Primary	Fat body mass	Fat body mass will be determined using the dual energy X-ray absorption (DEXA) method, using a densitometry machine (Hologic GE, Bedford, USA).	15 minutes
Primary	Muscle thickness	Muscle thickness will be evaluated through ultrasound (Nemio XG, Toshiba, Japan).	30 minutes
Primary	Muscle quality	Muscle quality will be evaluated through echo intensity of the quadriceps through ultrasound (Nemio XG, Toshiba, Japan).	30 minutes
Primary	Maximum dynamic strength	Maximum dynamic strength will be assessed using the 1 repetition maximum (1RM) test for bench press and knee extension exercises.	30 minutes
Primary	Maximum power	The maximum power and the medium power will be evaluated in the bench press and knee extension exercises considering a load of 30 and 70% of 1RM.	30 minutes