The Joint Effect of Air Pollution and Exercise on Cognitive Function

Exercise Clinical Trial

Official title:

The Joint Effect of Air Pollution and Exercise on Cognitive Function

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04830059
• Other study ID #: THU2021
• Status: Active, not recruiting
• Phase: N/A
• Start date: November 1, 2020
• Est. completion date: July 10, 2021

Study information

• Verified date: April 2021
• Source: Tsinghua University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A double-blind randomized controlled trial design is used in this study. A mixed design of 2 (pollution reduction group vs. no pollution reduction group) × 3 (high intensity intermittent exercise [HIIT], moderate intensity of aerobic exercise [MICT] and control group [CONT]) is used. 93 subjects recruited by advertising will be randomly divided into 6 groups: high intensity exercise group (pollution reduction vs no pollution reduction), moderate intensity aerobic exercise group (pollution reduction vs no pollution reduction) and Stretching group (Control) (pollution reduction vs no pollution reduction).

Description:

Environmental intervention program In the pollution reduction groups, the air purification system is used 2 hours before the subjects entered the room to minimize the indoor PM2.5 and PM10. Exercise intervention program including HIIT, MICT and Stretching (Control) group : The VO2max of all subjects are measured one week before the experiment. HIIT program: 20 minutes exercise of HIIT (1min of 100% VO2max and 1min of 50% VO2max alternately) and 10 minutes of warm-up and relaxation. MICT program: 20 minutes exercise of 70-75% VO2max and 10 minutes of warm-up and relaxation. Stretching control group: 30 minutes of stretching, posture adjustment and rehabilitation courses taught by professional therapists.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 93
• Est. completion date: July 10, 2021
• Est. primary completion date: June 10, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 30 Years

Eligibility

Inclusion Criteria:

• No regular exercise in the past six months;
• Healthy people without history of disease;
• Aged between 20 and 30 years old.

Exclusion Criteria:

• Professional athletes;
• Regular exercise in the past six months;
• People who are injured or have a history of disease in the past six months;
• People who have a history of taking medicine in the past six months.

Related Conditions & MeSH terms

• Air Pollution
• Cognition
• Exercise
• Health Promotion

Intervention

Behavioral:
• Exercise
Two types of exercise intervention and control group
• Air purification
Air purification in order to reduce the PM2.5 and PM10

Locations

Country	Name	City	State
China	Tsinghua University	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Tsinghua University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change of cognitive function	Cognitive function measured by computer-based tasks including executive function	Before and after acute exercise (about 30 minutes).
Primary	Change of biomarkers	The cognitive-related biomarkers including brain derived neurotrophic factor	Before and after acute exercise (about 30 minutes).
Primary	Change of oxyhemoglobin	Mearsurement of oxyhemoglobin using fNIRS	Before and after acute exercise (about 30 minutes).
Primary	Change of transcriptions	The molecular response of exercise and environment through the measurement of peripheral blood	Before and after acute exercise (about 30 minutes).
Primary	Change of metabonomics	The molecular response of exercise and environment through the measurement of peripheral blood	Before and after acute exercise (about 30 minutes).
Primary	Change of cerebral blood flow	The blood flow of middle cerebral artery measured by ultrasonic doppler	Before and after acute exercise (about 30 minutes).
Secondary	Change of cognitive function	Cognitive function measured by computer-based tasks including executive function	Three months (from baseline to the third month)
Secondary	Change of aerobic capacity	The aerobic capacity measured by the gas metabolism analyzer	Three months (from baseline to the third month)
Secondary	Change of cerebral blood flow	The blood flow of middle cerebral artery measured by ultrasonic doppler	Three months (from baseline to the third month)
Secondary	Change of biomarkers	The cognitive-related biomarkers including brain derived neurotrophic factor	Three months (from baseline to the third month)
Secondary	Change of oxyhemoglobin	Mearsurement of oxyhemoglobin using functional near infrared spectroscopy	Three months (from baseline to the third month)
Secondary	Change of metabonomics	The molecular response of exercise through the measurement of peripheral blood	Three months (from baseline to the third month)
Secondary	Change of transcriptions	The molecular response of exercise through the measurement of peripheral blood	Three months (from baseline to the third month)