Exercise Clinical Trial
Official title:
Cortical Neuroplasticity by Muscle Pain and Non-invasive Modulation of Pain-induced Plasticity
The purpose of this study is to investigate the sensory-motor cortical excitability response to delayed onset muscle soreness (DOMS) on Extensor Carpi Radialis (ECR) muscle during muscle hyperalgesia provoked by nerve growth factor (NGF).
The purpose of this study is to assess changes in sensory-motor cortical excitability during
experimental muscle hyperalgesia across several days provoked by injections of nerve growth
factor (NGF) into the Extensor Carpi Radialis (ECR) muscle and delayed onset muscle soreness
(DOMS) of the ECR muscle.
It was hypothesized that muscle hyperalgesia across several days would result in:
i) Increased sensory cortical excitability, based on somatosensory evoked potentials by means
of electrical stimulation of the radial nerve, (increase of central-parietal evoked-potential
P45 and decrease of frontal evoked-potential N30); ii) Increased corticomotor excitability of
a ECR (increase map volume and number of active sites), assessed as motor evoked potentials
induced by transcranial magnetic stimulation in primary motor cortex (M1); iii) Reduction of
alpha oscillation based on nociceptive stimulus-evoked suppression of alpha activity in
sensory regions (recording electrodes on contra-lateral parietal area);
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