Exercise Intervention on Conflict Monitoring in Children With Attention-deficit Hyperactivity Disorder

Exercise Intervention Clinical Trial

— ADHD  

Official title:

The Effect of Long-term High-intensity Interval Training on Conflict Monitoring in Children With ADHD: an ERP and sLORETA Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04112758
• Other study ID #: 201903HM013
• Status: Completed
• Phase: N/A
• Start date: June 1, 2020
• Est. completion date: January 23, 2022

Study information

• Verified date: January 2023
• Source: National Taiwan Normal University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study mainly investigates the effect of high-intensity interval training on conflict monitoring in children with ADHD by using event-related potential and sLORETA techniques.

Description:

The present study will have two experiments, one is a cross-section study and the other is intervention study.

As for cross-section study, typical developmental children and children with ADHD will perform the stroop task while recording their brain waves.

The intervention is twice a week for 5 weeks and before and after the intervention, children with ADHD will randomly assign to either an exercise group or control group. They will perform the stroop task while recording their brain waves.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 110
• Est. completion date: January 23, 2022
• Est. primary completion date: April 30, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 7 Years to 12 Years

Eligibility

Inclusion Criteria:

1. age between 7 and 12 years

2. diagnosed with ADHD by a pediatric psychiatrist, which is not required for TD

3. no history of brain injury or neurological conditions, such as exhibited epileptic seizures, serious head injuries, and periods of unconsciousness.

Exclusion Criteria:

1. cannot follow the instruction

2. cannot complete all the procedure

Related Conditions & MeSH terms

• Exercise Intervention

Intervention

Other:
• High-intensity interval training
2 times weekly for 5 weeks Circuit training with 4 stations

Locations

Country	Name	City	State
Taiwan	National Taiwan Normal University	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan Normal University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Brain activation	To examine sources relating to amplitude in ERPs, source localization will be conducted using standardized low resolution brain electromagnetic tomography (sLORETA) The sLORETA analysis with the ERP data will be selected by four 100 ms bins covering the period from 0 to 200 ms after stimulus-onset (0-50, 50-100, 100-150, and 150-200 ms).	Day 0 and post-intervention at Week 5
Primary	Behavioral performance	reaction time (ms) is generated by computerized task de?ned as correct responses within the range from 200-1500 ms	Day 0 and post-intervention at Week 5
Primary	Behavioral performance	response accuracy (percentage) is generated by computerized task defined as percentage of trials that successfully responded to target stimulus	Day 0 and post-intervention at Week 5
Secondary	N2 & P3 components	Electroencephalographic (EEG) activity will be measured at 64 sites. The amplitude of the N2 is de?ned as the mean amplitude within a 50-ms interval surrounding the maximal negative peak within a 200- to 400-ms latency window.; The amplitude of the P3 is de?ned as the mean amplitude within a 50-ms interval surrounding the maximal positive peak within a 300- to 800-ms latency window.	Day 0 and post-intervention at Week 5