Exercise-induced Inflammation Clinical Trial
Official title:
Effect of 4 Weeks Fish Oil Supplementation on Cycling Performance or Oxidative and Inflammatory Parameters in Healthy Male Cyclists
Verified date | June 2017 |
Source | Loughborough University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Research Plan
Eleven trained cyclists have completed 4 cycling performance trials, before and after 4 weeks
of fish oil supplementation and before and after 4 weeks of placebo with a 4 week washout
between supplementation periods. During the performance trials blood, expired air and heart
rate were collected. The blood samples have been used to investigate the production of
inflammation resulting from the cycling performance test. Inflammation has been assessed
using enzyme-linked immunosorbent assay for IL-6, which is an inflammatory cytokine. Work
done from the cycling performance will be analysed to investigate whether there is a
relationship with power and inflammation and whether this is modulated by fish oil
supplementation.
Specific Aims
1. Does 4 weeks of Fish Oil supplementation attenuate the inflammatory response following
high intensity cycling.
2. Is a modulation of the inflammatory response connected to cycling performance.
Hypotheses
1. Four weeks of n3-PUFA supplementation will reduce the inflammatory response
2. A reduction in inflammation will improve cycling performance
Anticipated Outcomes
A high level of cycling performance, indicated by a high average power, will be associated
with high levels of systemic inflammation. n3-PUFA supplementation will decrease the level of
inflammation and consequently cycling performance will be improved.
Status | Completed |
Enrollment | 12 |
Est. completion date | December 2014 |
Est. primary completion date | December 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - recreationally trained male cyclists Exclusion Criteria: - History of coagulation/bleeding disorder - History of metabolic disease - Serious allergy - History of heart disease - Regular use of anti-inflammatory drugs - Vitamin or fish oil supplementation over the past 6 months - Known to have blood-borne virus - Females |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Loughborough University | University of Worcester |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Work Done | Work done measured in Joules from the Lode cycle ergometer during 15 minute cycling time trial | 15 minutes during time trial |
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