Exercise Induced Asthma Clinical Trial
Official title:
Mediator Release During Exercise-induced Bronchoconstriction
This study will compare the inflammatory response in induced vs inhibited exercise induced bronchoconstriction (EIB) in patients with a medical diagnosis of asthma/EIB. Urinary and plasma samples will be analysed to compare the mediator release in each condition, alongside changes in lung function.
Exercise induced-bronchoconstriction (EIB) is a transient narrowing of the airways that
occurs during or shortly after strenuous exercise. The prevalence of EIB in asthmatic
patients is estimated around 30-50%, but EIB can also occur in individuals without asthma
(especially children, army recruit forces, and elite athletes). Controversy remains about the
causative mediators in the bronchoconstrictive response. Technological advancement in mass
spectrometry has opened new avenues in the quantitative measurement of small endogenous
metabolites in biological fluids (including urine and blood), which may provide insights into
the pathophysiology of EIB and direct future therapeutic targets.
Utilising novel techniques in the analysis of inflammatory mediators in urine and blood, this
study aims to conduct the most comprehensive analysis of mediator release during EIB to date.
Participants will attend a screening visit during which they will complete an exercise
challenge (to determine the presence of EIB). A skin prick test will also be conducted to
establish the atopic status of the participants. Following the screening visit, patients with
EIB will be invited to complete a randomised cross-over study, where they will perform two
further exercise challenges on separate days: one while inhaling temperate dry air, and one
while inhaling hot humid air (the latter is known to inhibit EIB). Lung function and
breathing discomfort will be recorded, and urine and blood samples will be collected, before
and at various time points after exercise. As a control condition, participants will also
attend one visit during which no exercise will be performed.
Participants aged 18-50yr, with diagnosed asthma and/or EIB, will be included in the study.
12 participants will complete 4 visits (lasting between 90 min and 4.5h). The study will take
place on Brunel University London campus, Uxbridge. Urine and blood samples will be sent to
the Karolinska Institutet, Stockholm, Sweden for analysis.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Enrolling by invitation |
NCT05162703 -
Evaluation of Exercise Induced Bronchoconstriction Using a Novel Automated Digital Clinical Decision System
|
N/A | |
Completed |
NCT00989833 -
Comparing Symbicort® As-Needed or Bricanyl As-Needed or Pulmicort® Once Daily + Bricanyl As-Needed in Asthma Patients
|
Phase 2 | |
Completed |
NCT03550456 -
Diagnostics and Quality of Life With EIA and EILO
|
||
Completed |
NCT00861185 -
Study to Assess Safety and Efficacy of Oral Senicapoc Administration on Exercise-induced Asthma
|
Phase 2 | |
Completed |
NCT05703334 -
Kt and Myofascial Release in Exc Asthma
|
N/A | |
Recruiting |
NCT05105529 -
Adaptation to Ozone in Individuals With Asthma/Exercise-induced Bronchoconstriction
|
N/A | |
Terminated |
NCT01070888 -
Trial on the Effect of Budesonide/Formoterol and Inhaled Budesonide Alone on Exercise-Induced Asthma
|
Phase 4 | |
Recruiting |
NCT06336681 -
Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Time-Trial Performance (IMT_EIB)
|
Phase 2 | |
Completed |
NCT01942096 -
Study of Airway Inflammation in Relation to Exercise in Elite Athletes
|
||
Completed |
NCT00127166 -
Two Investigational Drugs in the Prevention of Airway Constriction Brought on by Exercise in Participants With Asthma (0476-911)
|
Phase 3 | |
Recruiting |
NCT05174689 -
Epigenetic Regulation of Exercise Induced Asthma
|
N/A | |
Completed |
NCT01097954 -
A Prospective Study Measuring Exhaled Nitric Oxide in Exercise-Induced Asthma
|