Exercise Anaphylaxis Clinical Trial
Official title:
The Impact of High Intensity Exercise Upon EPC Number and Function in Young Women
The purpose of the study is to examine the effects of different exercise intensity training programs upon blood vessel function and circulating blood cells involved in blood vessel repair in young women. The long term effects of exercise may be beneficial to cardiovascular health and it is important to understand the training methods that are the most beneficial. In particular we aim to determine if brief maximal exercise improves the function and stiffness of blood vessels and enhance blood vessel repair. Two methods of exercising are being compared, exercise bouts involving intermittent exercise and exercise completed all at once, but at a very high intensity.
| Status | Not yet recruiting |
| Enrollment | 12 |
| Est. completion date | November 2012 |
| Est. primary completion date | September 2012 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | Female |
| Age group | 18 Years to 25 Years |
| Eligibility |
Inclusion Criteria: - Young healthy females - Between 18-25 years old - No on medication (this includes contraceptives) Exclusion Criteria: - Medication use (including oral contraceptives) - Amenorrhoea - High blood pressure - Very active (>3 hours per week of organized physical activity) |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
| Country | Name | City | State |
|---|---|---|---|
| United Kingdom | University of Leeds | Leeds | West Yorkshire |
| Lead Sponsor | Collaborator |
|---|---|
| University of Leeds |
United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Maximal oxygen uptake | A measure of aerobic capacity determined during an incremental exercise test to volitional fatigue on an exercise ergometer. | 4 weeks | Yes |
| Secondary | Heart rate variability | 4 weeks | No | |
| Secondary | Endothelial progenitor cell function | measures of in vitro cell migratory ability, adhesion and classification of endothelial progenitor cells | 4 weeks | No |
| Secondary | Flow mediated dialtion | Measure of vascular endothelial function determined non-invasively at the brachial artery | 4 weeks | No |
| Secondary | Arterial stiffness | The stiffness of the carotid artery is measured using a combination of ultrasound imaging and non-invasive blood pressure measurements. Lower degrees of stiffness are more favourable. | 4 weeks | Yes |
| Secondary | Circulating angiogenic cell numbers | These cells are involved in vascular repair and proliferation and may be measured using flow cytometric methods. Specifically cells with CD34 and CD309 antigens are enumerated. | 4 weeks | No |
| Secondary | Endothelial progenitor cell function | Measure of in vitro migratory, adhesion and classification of endothelial progenitor cells. | 4 weeks | No |