Executive Dysfunction Clinical Trial
Official title:
A Clinical Study to Explore the Effect of Repetitive Transcranial Magnetic Stimulation on Abnormal Executive Function of High Function Autism Spectrum Disorder Children
In this study, the investigators will explore the effects of repetitive transcranial magnetic stimulation (rTMS) on executive function deficits in high function autism spectrum disorder. Half of the participants will be chosen by chance to receive continuous theta burst stimulation (cTBS) while the other half will be chosen by chance to receive sham stimulation. And finally the sham group individuals also receive cTBS. Based on results from a recent unpublished pilot data, the investigators propose that cTBS treatment will induce a significant improvement in executive function performance compared to sham treatment.
This study is a randomized, sham controlled study to evaluate the efficacy of cTBS as a
treatment for executive function deficits in individuals with autism spectrum disorder
between 6 and 16 years of age. The study duration is approximately 1 months, with the cTBS
sessions lasting for 4 weeks, 5 times a week, for about 20min each. Several scales will be
used to assess for symptom severity and adaptive functioning. The executive function will be
evaluated by Behaviour Rating Inventory of Executive Functioning (BRIEF) questionnaire.
Cognition will be assessed using functional near - infrared spectroscopy (fNIRS).
This study also involves a type of brain imaging known as magnetic resonance imaging (MRI) at
the beginning and at the end of the 4 weeks daily cTBS to better understand the effects of
cTBS on brain structure and function. Investigators will measure the size and connections of
different parts of the brain to assess brain structure and blood flow.
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