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Clinical Trial Summary

The investigators explored the activity of anlotinib combined with irinotecan in patients with relapsed and metastatic Ewing Sarcoma.


Clinical Trial Description

After standard multimodal therapy, the prognosis of relapsed and metastatic Ewing Sarcoma is dismal and unchanged over the last decades.Thus, the investigators explored the activity of anlotinib combined with irinotecan in patients with relapsed and metastatic Ewing Sarcoma after the failure of first-line chemotherapy with doxorubicin, vincristine, cyclophosphamide, ifosphamide and etoposide. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03416517
Study type Interventional
Source Peking University People's Hospital
Contact Wei Guo, M.D, Ph.D
Phone 86 010 88326152
Email bonetumor@163.com
Status Recruiting
Phase Phase 1/Phase 2
Start date January 22, 2018
Completion date December 2020

See also
  Status Clinical Trial Phase
Completed NCT02736565 - Pbi-shRNAâ„¢ EWS/FLI1 Type 1 LPX in Subjects With Advanced Ewing's Sarcoma Phase 1
Not yet recruiting NCT02982486 - A Phase II of Nivolumab Plus Ipilimumab in Non-resectable Sarcoma and Endometrial Carcinoma Phase 2
Terminated NCT03495921 - A Trial For Participants With Ewing's Sarcoma Treated With Vigil in Combination With Irinotecan and Temozolomide Phase 3
Temporarily not available NCT03842865 - Expanded Access of Vigil in Solid Tumors