Clinical Trials Logo
  1. Home
  2. Eustachian Tube Dysfunction
  3. NCT04404036

Treatment of Eustachian Tube Dysfunction (ETD) and Facial Pain With Combined Acoustic Vibration and Oscillating Expiratory Pressure

Eustachian Tube Dysfunction Clinical Trial

Official title:
Treatment of Eustachian Tube Dysfunction (ETD) and Facial Pain With Combined Acoustic Vibration and Oscillating Expiratory Pressure

Clinical Trial Summary

This study aims to test the safety, efficacy and potential mechanism of action of the SinuSonic device on adults with eustachian tube dysfunction (ETD) or facial pain/pressure. SinuSonic is a medical device that utilizes sound and pressure combined with normal breathing. The study will have 3 aims. Aim 1 will examine healthy controls with no signs of upper respiratory infection, inflammation, or ETD to determine if exhaled nasal Nitric Oxide is increased. Nitric Oxide is a compound in the body that acts as a blood vessel relaxant. Acoustic energy (humming) has been shown to increase nasal Nitric Oxide dramatically, thus equalization of gas pressures between the middle ear, the paranasal sinuses and the nasal cavity may very well explain any efficacy noted. Aim 2 will be performed to examine therapeutic efficacy for ETD. Aim 3 will be performed to examine therapeutic efficacy for sinus pain/pressure.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04404036
Study type Interventional
Source Medical University of South Carolina
Contact Matthew Germroth
Phone 8438761166
Email germroth@musc.edu
Status Recruiting
Phase N/A
Start date August 11, 2020
Completion date July 1, 2025
View Details
See also
  Status Clinical Trial Phase
Completed NCT04776967 - Effect of Total Compression Time and Rate (Slope) on Incidence of Symptomatic ETD and MEB: A Phase II Prospective Study. N/A
Recruiting NCT04804098 - Effect of Rate (Slope) of Compression on the Incidence of Symptomatic ETD and MEB: a Phase III Prospective Study. N/A
Terminated NCT01974726 - Gas Supply, Demand and Middle Ear Gas Balance -- Diagnosis of Eustachian Tube Dysfunction N/A
Recruiting NCT05600595 - The Evaluation of Eustachian Tube Function and Its Influencing Factors After Snoring Operation in Children
Not yet recruiting NCT05998356 - Long-term Assessment of Balloon Eustachian Tuboplasty for Obstructive Eustachian Tube Disease N/A
Not yet recruiting NCT03322579 - Balloon Dilation of the Eustachian Tube, a Lower Pressure Challenge N/A
Withdrawn NCT03886740 - Tympanostomy Tubes Versus Eustachian Tube Dilation N/A
Completed NCT04809753 - Eustachian Tube Dilation With an Endovascular Balloon N/A
Withdrawn NCT02631187 - Feasibility Study of Balloon Eustachian Tuboplasty (BET) N/A
Completed NCT04902963 - What is the Tympanic Membrane Healing Time After Insertion of a Gelfoam PE Tube? N/A
Completed NCT04136977 - XprESS ET Registry
Completed NCT03197558 - Adult Study to Evaluate Placement of Tympanostomy Tubes In-office (ADEPT) Phase 2
Recruiting NCT05719207 - Efficacy of Balloon Dilation of the Eustachian Tube in Eustachian Tube Dilatory Dysfunction N/A
Completed NCT01251432 - Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults N/A
Recruiting NCT04645511 - Balloon Sinuplasty Efficiency in Maxillary Rhinosinusitis. N/A
Recruiting NCT05055115 - Ph.D.-Project: Eustachian Tube Dysfunction: Causes, Diagnosis, Treatment, and Prognosis N/A
Not yet recruiting NCT05222230 - FFP3 Respirators and Ears - Effects on Middle Ear Pressure and Hearing N/A
Completed NCT02667301 - Eustachian Tube Dysfunction Assessment N/A
Not yet recruiting NCT05229380 - Pretympanoplasty Assessment of Patency and Mucociliary Function of Eustachian Tube
Completed NCT03850197 - Tubomanometry and EarPopper Devices for Eustachian Tube Function Testing