Directional Versus Nondirectional DBS for ET

Status Recruiting

Clinical Trial Summary

This will be a single center (OHSU) proof of concept trial to demonstrate that directional deep brain stimulation (DBS) creates a larger therapeutic window for the treatment of essential tremor (ET), effectively treats ET, and minimizes effects on speech, gait and balance compared to nondirectional DBS.

Clinical Trial Description

Specific Aims: 1. To compare the therapeutic window (TW) of directional versus nondirectional deep brain stimulation for treatment of tremor. Hypothesis: directional DBS will result in a wider TW than nondirectional DBS. 2. To compare the effects of directional versus nondirectional DBS on speech Hypothesis: Objective and subjective speech impairment will occur to a greater extent in nondirectional DBS versus directional DBS optimized for tremor control. 3. To compare the effects of directional versus nondirectional DBS on balance and gait Hypothesis: Objective and subjective balance and gait impairment will occur to a greater extent in nondirectional DBS versus directional DBS optimized for tremor control. 4. To assess efficacy for tremor of nondirectional and directional DBS in an optimized programming configuration Hypothesis: both directional and nondirectional DBS will significantly improve tremor compared to baseline. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04828798
Study type	Interventional
Source	Oregon Health and Science University
Contact	Zoe Fanning
Phone	503-494-7772
Email	fanningz@ohsu.edu
Status	Recruiting
Phase	N/A
Start date	April 1, 2021
Completion date	February 8, 2024

View Details

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