End Stage Renal Disease Clinical Trial
Addition of Heparin to the Catheter Lock Solution (CLS): Taurolock-TM will improve the vascular patency compared to Taurolock-TM alone , in hemodialysis patients with Tunneled Cuffed Catheter(TCC) as vascular access.
Bacteremia and thrombosis are the major complications of TCC used for
hemodialysis.Instilation of CLS containing antibiotic-anticoagulant solution in the end of
each dialysis session till the next dialysis ,can prevent Catheter related bacteremia
(CRB).In previous study in our department, Taurolock-TM decreased the rate of CRB but
increased the incidence of catheter malfunction.
The aim of the study is to investigate the influence of of Heparin addition to
CLS-Taurolock- TM ( Taurolidine &citrate 4%) in prevention of catheter patency problems in
HD patients with TCC, in addition to CRB prevention.
Methods : Patients with newly inserted TCC for HD enrolled and randomized to receive one of
three CLS types : group 1- Taurolock-TM, Group 2 - Taurolock-TM and Heparin , Group 3-
Heparin .Patients were followed for 6 monthes.
The objective of the study is to investigate the effect of Taurolock TM with heparin on the
rate of CRB and vascular patency.
;
Primary Purpose: Prevention
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