Histological/ Immunohistological and Molecularpathological Types of Epulides and Central Giant Cell Lesions of the Jaws

Epulis Clinical Trial

Official title:

Retrospective Clinico-pathological Examinations on Different Histological/ Immunohistological and Molecularpathological Types of Epulides and Central Giant Cell Lesions of the Jaws

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03829059
• Other study ID #: GCG
• Status: Active, not recruiting
• Start date: June 1, 2018
• Est. completion date: February 2026

Study information

• Verified date: October 2023
• Source: Medical University of Graz
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This retrospective study will evaluate the patient collective of the Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health and of the Division of Cranio-Maxillofacial Surgery at the Medical University Graz concerning the frequency of epulis/giant cell lesion or underlying differential diagnoses and immunophenotypes as well as the resulting treatment methods and their success and compare these with international results

Description:

Different histopathological differential diagnoses can underlay the clinical presentation of an epulis. Often the immunophenotype of these lesions is of particular importance. This also holds for the the central giant cell lesion. This study will evaluate the patient collective of the Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health and of the Division of Cranio-Maxillofacial Surgery at the Medical University Graz concerning the frequency of epulis/giant cell lesion or underlying differential diagnoses and immunophenotypes as well as the resulting treatment methods and their success and compare these with international results. This is a retrospective study using electronic patient records, written records, operative reports of the Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health and of the Division of Cranio-Maxillofacial Surgery at the Medical University Graz in the period from 1986 to March 2018. It is intended to gather the data within 12 months and analyze statistically subsequently.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 83
• Est. completion date: February 2026
• Est. primary completion date: February 2026
• Accepts healthy volunteers: No
• Gender: All
• Age group: 7 Years to 95 Years

Eligibility

Inclusion Criteria:

• existence of a medical history and a histopathological finding of the surgical specimen
• patients treated in the outpatient clinic for diseases of oral mucosa of the Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health and of the Division of Cranio-Maxillofacial Surgery at the Medical University Graz between 1986 and March 2018

Exclusion Criteria:

• absence of a medical history or a histopathological finding.

Related Conditions & MeSH terms

• Epulis
• Gingival Diseases

Locations

Country	Name	City	State
Austria	Medical University	Graz

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of Graz

Country where clinical trial is conducted

Austria, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Frequency of histological pathological differential diagnoses.		time period of evaluation from 1986 to March 2018
Primary	Frequency of immunohistochemical pathological differential diagnoses.		time period: from 1986 to March 2018
Primary	Frequency of molecular pathological differential diagnoses.		time period from 1986 to March 2018
Secondary	Frequency of recurrences	depending on differential diagnoses and therapy	time period from 1986 to March 2018