Fourier Transformed Infrared Spectroscopy in Macular Surgery

Status Completed

Clinical Trial Summary

Epiretinal membranes (ERM) are disorders leading to vision loss and metamorphopsia. Vitrectomy with membrane peeling has developed to be the gold-standard in treatment of ERM. ERM can be well visualized with spectral domain optical coherence tomography (SD-OCT).

The aim of the study is to examine ERM and internal limiting membranes (ILM) exzised during routine macular surgery with fourier transformed infrared spectroscopy (FTIR) and compare results to optic coherence tomography (OCT) findings.

Clinical Trial Description

Purpose of the present study is to analyse components of ERM and ILM, giving hints for the origin of cells producing ERM. In contrast to electron microscopy, FTIR spectroscopy does not need any chemical fixation of the membranes and therefore structure of components of ERM and ILM are not changed by fixation.

In total, 20 eyes with idiopathic ERM, 10 eyes with lamellar macular hole, 10 eyes with full thickness macular hole and 10 eyes with diabetic ERM will be examined. To our knowledge there are no previous reports about FTIR spectroscopy of ERM and ILM, therefore the study will be performed as an exploratory pilot study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03452748
Study type	Interventional
Source	Vienna Institute for Research in Ocular Surgery
Contact
Status	Completed
Phase	N/A
Start date	January 1, 2017
Completion date	June 1, 2019

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03332758` - Inflammasomes in Cell Death in FTMH, ERM, and RRD
Active, not recruiting	`NCT04130841` - Effects of Internal Limiting Membrane Peeling on Visual Function in Epiretinal Membrane Surgery	N/A
Recruiting	`NCT03713268` - Intraoperative OCT Guidance of Intraocular Surgery II
Terminated	`NCT01532765` - Randomized Trial Comparing Epiretinal Membrane Surgery With and Without Internal Limiting Membrane Removal	N/A
Completed	`NCT01474655` - Retinal Layers and Visual Rehabilitation After Epiretinal Membrane Removal	N/A
Active, not recruiting	`NCT04120311` - Episcleral Dexamethasone for Treatment of Macular Edema and Inflammatory Disorders of the Posterior Pole	Phase 1
Completed	`NCT04445142` - Fovea ERM After Fovea-sparing ILM Peeling
Recruiting	`NCT01701518` - A Pilot Study of the Effectiveness of Intra-operative Ozurdex® in Vitrectomy Surgery for Epiretinal Membranes	N/A
Completed	`NCT01627977` - Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy	Phase 3
Completed	`NCT01771939` - Phacoemulsification and 25 Gauge (25G) Vitrectomy Versus Phacoemulsification Only in Idiopathic Epiretinal Membranes	N/A
Completed	`NCT00408720` - Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies	N/A
Completed	`NCT05171621` - Measuring Subjective Quality of Vision and Metamorphopsia Before and After Epiretinal Membrane and Macular Hole Surgery
Active, not recruiting	`NCT04306718` - Cultivation of Hyalocytes From ILM and ERM Samples: a Pilot Study	N/A
Recruiting	`NCT01985490` - Change in Foveal Avascular Zone After Removal of Epiretinal Membrane and Internal Limiting Membrane	N/A
Completed	`NCT01238393` - Treatment of Epiretinal Membranes With Ranibizumab	N/A
Terminated	`NCT00333060` - Study of OT-551 Eye Drops to Prevent or Delay Progression of Nuclear Cataracts Following Vitreous Removal	Phase 2
Completed	`NCT05287269` - Ocular Coherence Tomography During Cataract Assessment
Recruiting	`NCT05138315` - Quantification of Metamorphopsia in Patients With Epiretinal Membranes	N/A
Recruiting	`NCT03661593` - Aniseikonia in Epiretinal Membrane Patients	N/A
Completed	`NCT03457584` - Effect of Air-tamponade on Intraretinal Cystoid Changes After Membrane Peeling	N/A