Evaluating the Role of Inflammation in Neonatal Epileptogenesis — NSR-RISE  

Epilepsy Clinical Trial

Official title: Neonatal Seizure Registry: The Role of Inflammation After Neonatal Seizures and Later Development of Epilepsy

Status Active, not recruiting

Clinical Trial Summary

The purpose of this study evaluate the relationship between inflammation and epilepsy in neonates with seizures after birth.

Clinical Trial Description

Seizures are a common symptom of neurologic dysfunction in the neonatal period, affecting more than 16,000 newborns in the United States per year. Over 25% of neonates with acute symptomatic seizures develop post- neonatal epilepsy (PNE), which is often resistant to medical therapies. There is a critical need to identify those patients most at risk for PNE and understand the mechanisms by which early seizures increase the propensity for recurrent seizures, in hopes of identifying novel therapeutic targets in this population. There is increasing evidence for the role of neuro-inflammation in the development of epilepsy. Levels of cytokines and micro-RNA (miRNA) may serve as markers of disease severity and have been implicated in epileptogenesis in animal models. The purpose of this study is to evaluate plasma cytokine and miRNA levels after neonatal-onset acute symptomatic seizures and determine their association with acute seizure severity and PNE. ;

Related Conditions & MeSH terms

• Epilepsy
• Inflammation
• Inflammatory Response
• Neonatal Seizure
• Seizures

• NCT number: NCT04259125
• Study type: Observational
• Source: University of California, San Francisco
• Status: Active, not recruiting
• Start date: December 15, 2018
• Completion date: November 30, 2024