Epilepsy Clinical Trial
— EpiCopOfficial title:
Prospective Study on Copeptin in Childhood Epilepsy
Verified date | September 2017 |
Source | University Hospital, Basel, Switzerland |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
In many fields of medicine, except seizure disorders, blood biomarkers have captured an integrated part of diagnostic decision making, including copeptin, the surrogate marker of vasopressin release. There are strong arguments to hypothesize circulating copeptin is elevated in epilepsy, especially in generalized seizures such as fever seizures (FS), and that copeptin is predictive for complexity and relapse at least in FS. Although long-term morbidity and mortality are both low in FS, there is high anxiety among parents because of a lack of criterions to identify children at risk for relapse. Copeptin may fill this gap by adding important diagnostic and prognostic information. Eventually, less children may receive needlessly over years fever drugs or anti-epileptic drugs.
Status | Completed |
Enrollment | 340 |
Est. completion date | March 2017 |
Est. primary completion date | December 2015 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A to 5 Years |
Eligibility |
Inclusion Criteria epilepsy-cohort: - All kind of seizures leading to presentation - Age below 6 years Inclusion Criteria control-cohort: - Fever without seizures caused by banal infections - Age below 6 years Exclusion Criteria: - No blood required for medical reasons |
Country | Name | City | State |
---|---|---|---|
Switzerland | University Children's Hospital Basel | Basel |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Basel, Switzerland | University Children's Hospital Basel |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | number of repeated events of seizures | relapse of seizures within 12 month | 12 month | |
Primary | Copeptin concentration in serum | at admission | ||
Secondary | base excess in blood gas analysis | at admission | ||
Secondary | prolactin | at admission | ||
Secondary | duration of seizures | at admission | ||
Secondary | Short term relapse of seizures | 24 hours after first presentation | ||
Secondary | sodium concentration | at admission | ||
Secondary | osmolality | at admission | ||
Secondary | hydrogen ion activity in blood gas analysis | hydrogen ion activity = pH | at admission |
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