Structural Cartography of the Insula in Temporal Epilepsy Patients

Epilepsy, Temporal Lobe Clinical Trial

— CON-INSULA  

Official title:

Structural Cartography of the Insula in Temporal Epilepsy Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04871555
• Other study ID #: 2020PI218
• Status: Not yet recruiting
• Start date: June 1, 2021
• Est. completion date: December 31, 2022

Study information

• Verified date: April 2021
• Source: Central Hospital, Nancy, France
• Contact: Louise Tyvaert, Pr
• Phone: 33383857723
• Email: l.tyvaert[@]chru-nancy.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy.

Description:

The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 115
• Est. completion date: December 31, 2022
• Est. primary completion date: April 30, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 15 Years and older

Eligibility

Inclusion Criteria:

• epileptic patients: temporal epilepsy or temporal plus epilepsy (temporomesial epilepsy, basal temporal epilepsy, mesio lateral or lateral epilepsy, temporo insular epilepsy, operculo insular epilepsy)
• patients who underwent video EEG monitoring with recorded seizures (at least one)
• patients who underwent a brain MRI with DTI sequence before epilepsy surgery
• patients who did not refuse the use of their clinical and MRI data for this study

Exclusion Criteria:

• patients younger than 15 years old
• patients with previous brain surgery (before MRI)
• uncompleted MRI sequences (DTI, T1 anatomical)

Related Conditions & MeSH terms

• Epilepsy
• Epilepsy, Temporal Lobe
• MRI Scans

Intervention

Other:
• MRI
structural imaging

Locations

Country	Name	City	State
France	Central Hospital nancy	Nancy

Sponsors (4)

Lead Sponsor	Collaborator
Central Hospital, Nancy, France	Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Hospices Civils de Lyon, University Hospital, Lille

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	cartography of insula in temporal epilepsy patients	Compared with healthy group, definition of different patterns of insular structural connectivity in epileptic patients	1 year after the last inclusion
Secondary	Correlation structural cartography and electroclinical data	correlation between patterns of insular structural connectivity and subtypes of epilepsy defined by electroclinical data	1 year after the last inclusion