Clinical Trials Logo
  1. Home
  2. Epilepsy Intractable
  3. NCT03014752

Comparison of the Effectiveness of the Outpatient Classical Ketogenic Diet and Modified Atkins Diet on Seizures Frequency, Nutritional Status and Some Biochemical Factors in Children and Adolescents With Intractable Epilepsy

Epilepsy Intractable Clinical Trial

Clinical Trial Summary

Epilepsy is one of a common neurological disorder. Antiepileptic drugs (AEDs) are usually the primary treatment of epilepsy. However, almost 30% of patients do not respond to AEDs and other treatments including ketogenic diet (KD) are used. The Ketogenic Diet (KD) is a low-carbohydrate, high fat, adequate-protein diet. In this study, investigators are going to compare two kinds of the ketogenic diet namely classical ketogenic diet and modified Atkins diet. Fifty children and adolescents with intractable epilepsy will be included, 25 patients in each group, and will receive the diet for three months on non-randomised basis. In the classical ketogenic diet, the diet with a ratio of 4 to 1 (4:1), each 4 grams of fat to each gram of carbohydrate plus protein, will be introduced. Classical ketogenic diet will be established on outpatient setting, without fasting and gradually. The modified Atkins diet will be applied by the ratio of 1:1 or 2:1, each 1 or 2 grams of fat to each gram of carbohydrate plus protein.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03014752
Study type Interventional
Source Tehran University of Medical Sciences
Contact
Status Completed
Phase Phase 2/Phase 3
Start date September 2016
Completion date May 2017
View Details
See also
  Status Clinical Trial Phase
Terminated NCT03790436 - Betaquik as an Adjunct to Dietary Management of Epilepsy in Adults on the Modified Atkins Diet N/A
Completed NCT05503511 - Safety and Pharmacokinetic Study of NPT 2042 Soft-gelatin Capsules Administered Orally to Healthy Adult Subjects Phase 1
Enrolling by invitation NCT04286776 - Memory Retrieval and Encoding Investigated by Neural Stimulation N/A
Completed NCT04763070 - Ciprofloxacin in Drug-resistant Epilepsy N/A
Completed NCT03403907 - The Effect of Probiotic Supplementation in Drug-resistant Epilepsy Patients N/A
Recruiting NCT04158531 - REC2Stim as a Treatment for Refractory Epilepsy in the Primary Sensorimotor Cortex. N/A
Recruiting NCT03289572 - Microgrid II - Electrocorticography Signals for Human Hand Prosthetics
Enrolling by invitation NCT05332990 - Multicenter Comparison of Interictal HFO as a Predictor of Seizure Freedom
Recruiting NCT04325360 - Effects of Transcranial Direct Current Stimulation (tDCS) for the Treatment of Refractory Epilepsy N/A
Active, not recruiting NCT05727943 - Add-on Clioquinol in Drug-resistant Childhood Epilepsy: an Exploratory Study Phase 2
Recruiting NCT04649008 - Localizing Epileptic Networks Using MRI and iEEG Early Phase 1
Active, not recruiting NCT03916848 - Novel Network Analysis of Intracranial Stereoelectroencephalography N/A
Completed NCT03646240 - ABI-009 (Nab-rapamycin) for Surgically-Refractory Epilepsy (RaSuRE) Phase 1
Recruiting NCT03857074 - Effects of Green Light Exposure on Epileptic Spikes in Patients With Refractory Epilepsy N/A
Enrolling by invitation NCT03702127 - TMS - Intracranial Electrodes N/A
Recruiting NCT05015868 - Contribution of Genetics, Non-invasive Methods and Neuropsychology in Focal Cryptogenic Epilepsies N/A
Enrolling by invitation NCT06138808 - 5-SENSE Score Validation Study
Not yet recruiting NCT03741192 - Impact of SPEAC® System Data on Therapeutic Decisions Related to Convulsive Seizure Patient's Refractory to AEDs N/A
Enrolling by invitation NCT05248269 - Thermocoagulation in Drug Resistant Focal Epilepsy N/A
Completed NCT04399954 - Evaluation of Ketoflo N/A