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Phenotype Assessment of Blood and Airway Eosinophils in Patients With COPD and Asthma

Eosinophilic Asthma Clinical Trial

Official title:
Phenotype Assessment of Blood and Airway Eosinophils in Patients With COPD and Asthma

Clinical Trial Summary

Around 1/3 of patients with COPD have elevated eosinophil levels. However, the role of eosinophils in COPD has not been yet understood and is probably different in COPD and in asthma. The aim of this study was to assess the expression of selected surface markers on eosinophils and to assess the gene expression in eosinophils in COPD and asthma patients. We are planning to enrol 12 COPD, 12 asthma and 12 control subjects. Patients will undergo routine clinical assessment, spirometry, blood sampling and sputum induction. Eosinophils will be isolated from blood and sputum. Surface markers on eosinophils will be assessed in flow cytometry, gene expression will be assessed by RNAseq.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05398133
Study type Observational
Source Medical University of Warsaw
Contact Katarzyna Gorska, MD PhD
Phone 22 599 27 53
Email drkpgorska@gmail.com
Status Recruiting
Phase
Start date September 1, 2020
Completion date June 2022
View Details
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