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Understanding Effects of Folic Acid on the Methylosome and Transcriptome of Women With Spina Bifida Affected Pregnancies

Environmental Exposure Clinical Trial

Official title:
Understanding Effects of Folic Acid on the Methylosome and Transcriptome of Women With Spina Bifida Affected Pregnancies

Clinical Trial Summary

Folic acid is currently considered to be the standard of care for primary and secondary prevention of spina bifida, but the mechanisms underlying folic acid's benefits are unknown. One hypothesis is that folic acid changes DNA methylation and transcription of genes important in neural tube closure. In this study, the investigators will evaluate how DNA methylation of genes associated with neural tube closure changes after a short course of standard-of-care folic acid supplementation. In addition, the investigators will assess whether environmental arsenic exposure modifies the effects of folic acid on the methylosome.

Clinical Trial Description

The investigators will encourage women who have recently had a pregnancy affected by spina bifida to take daily folic acid supplements for three months. Folic acid supplementation is considered standard of care for primary and secondary prevention of spina bifida. The investigators will compare DNA methylation in blood and folate levels before and after folic acid use. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05500690
Study type Interventional
Source Boston Children's Hospital
Contact Maitreyi Mazumdar, MD, MPH
Phone 617-355-2918
Email maitreyi.mazumdarmdmph@childrens.harvard.edu
Status Recruiting
Phase N/A
Start date October 8, 2023
Completion date November 2025
View Details
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