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Engraft Failure clinical trials

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NCT ID: NCT03821987 Recruiting - Aplastic Anemia Clinical Trials

Risk Stratification Directed Conditioning Regimen for Haploidentical HSCT in SAA

Start date: December 17, 2018
Phase: N/A
Study type: Interventional

The haplotype HSCT system including Bu(0.8mg/kg Q6hx2d)CTX(50mg/kgx4d)rATG(2.5mg/kgx4d) , established in Institute of Hematology of Peking University ,has been evaluated to be effective for acquired SAA.But some patients with high risk factors may not tolerate CTX 200mg/kg,alternative conditioning regimen including Bu/Fludarabine/dercreased CTX was studied in this trial.

NCT ID: NCT03818334 Recruiting - Clinical trials for Graft Versus Host Disease

Post Transplant Cyclophosphamide in Matched Unrelated Donor Stem Cell Transplantation for Hematological Malignancies

Start date: November 6, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

This study aims to evaluate the clinical efficacy of cyclophosphamide in patients receiving a bone marrow graft from a matched unrelated donor in overall survival, progression free survival and cumulative incidence of acute and chronic GvHD. Thirty patients will receive cyclophosphamide while twenty patients will receive antihuman T-lymphocyte immune globulin (ATG).