Endothelial Dysfunction Clinical Trial
Official title:
Ultrasound in the Intensive Care Unit and Measurable Indicators of Systemic Inflammation
Verified date | May 2021 |
Source | Osijek University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The aim of this study was to measure whether the flow rate through the brachial artery and inflammatory markers were associated with the development of tissue edema in the surgical intensive care unit patients.
Status | Completed |
Enrollment | 61 |
Est. completion date | December 30, 2021 |
Est. primary completion date | December 30, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Adults over 18 years of age - Postoperative surgical patients - Signed informed consent Exclusion Criteria: - Refusal to give informed consent - A previous thromboembolic event of the brachial artery - Acute infection of the upper extremity |
Country | Name | City | State |
---|---|---|---|
Croatia | Slavica Kvolik | Osijek |
Lead Sponsor | Collaborator |
---|---|
Osijek University Hospital | Josip Juraj Strossmayer University of Osijek |
Croatia,
Cavka A, Tadžic R, Grizelj I, Unfirer S, Mihaljevic Z, Mihalj M et al. Endotelna funkcija - funkcionalni pokazatelj kardiovaskularnih rizicnih cimbenika. Medicinski vjesnik [Internet]. 2012 [Accessed 23.05.2021.];44((1-4)):135-146. Available from: https://hrcak.srce.hr/187756
Chakraborty RK, Burns B. Systemic Inflammatory Response Syndrome. [Updated 2021 Jul 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547669/
Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017 Dec 14;9(6):7204-7218. doi: 10.18632/oncotarget.23208. eCollection 2018 Jan 23. — View Citation
Evans DH. Colour flow and motion imaging. Proc Inst Mech Eng H. 2010;224(2):241-53. doi: 10.1243/09544119JEIM599. — View Citation
Kubler A, Maciejewski D, Adamik B, Kaczorowska M. Mechanical ventilation in ICUs in Poland: a multi-center point-prevalence study. Med Sci Monit. 2013 Jun 3;19:424-9. doi: 10.12659/MSM.883930. — View Citation
Lu D, Kassab GS. Role of shear stress and stretch in vascular mechanobiology. J R Soc Interface. 2011 Oct 7;8(63):1379-85. doi: 10.1098/rsif.2011.0177. Epub 2011 Jul 6. — View Citation
Mortaz E, Alipoor SD, Adcock IM, Mumby S, Koenderman L. Update on Neutrophil Function in Severe Inflammation. Front Immunol. 2018 Oct 2;9:2171. doi: 10.3389/fimmu.2018.02171. eCollection 2018. — View Citation
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Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Diameter of brachial artery - 1 | Measurement of a brachial artery diameter [cm] at admission. Admission day is considered as day 1. | within 4 hours of admission. | |
Primary | Diameter of brachial artery - 2 | measurement of a brachial artery diameter [cm] on day 2 after admission. | day 2 after admission is between 24 and 48 hours after admission. | |
Primary | Brachial artery flow velocity - 1 | measurement of a brachial artery flow velocity [cm/s] at admission. | within 4 hours of admission to ICU. | |
Primary | Brachial artery flow velocity - 2 | measurement of a brachial artery flow velocity [cm/s] on day 2 after admission. Day 2 is Measurement of a brachial artery flow velocity [cm/s] between 24 and 48 h after ICU admission. | day 2 after admission is between 24 and 48 hours after admission. | |
Primary | Distance from skin to third metacarpal bone -1 | measurement of a distance from the skin to third metacarpal bone (cm) at admission. | within 4 hours of admission. | |
Primary | Distance from skin to third metacarpal bone - 2 | measurement of a distance from the skin to third metacarpal bone (cm) on day 2 after admission. | day 2 after admission is between 24 and 48 hours after admission. | |
Primary | White blood cell count - 1 | blood sample analysis for white blood cell count (WBC [10^9/L]) at admission. | within 4 hours of admission. | |
Primary | White blood cell count - 2 | blood sample analysis for white blood cell count (WBC [10^9/L]) on day 2 after admission. | day 2 after admission is between 24 and 48 hours after admission. | |
Primary | C-reactive protein - 1 | blood sample analysis for C-reactive protein (CRP [mg/L]) concentration at admission. | within 4 hours of admission. | |
Primary | C-reactive protein - 2 | Blood sample analysis for C-reactive protein (CRP [mg/L]) concentration on day 2 after admission. | day 2 after admission is between 24 and 48 hours after admission. | |
Primary | Procalcitonin - 1 | blood sample analysis for Procalcitonin concentration (PCT [ug/L]) at admission. | within 4 hours of admission. | |
Primary | Procalcitonin - 2 | Blood sample analysis for Procalcitonin concentration (PCT [ug/L]) on day 2 after admission. | Day 2 after admission is between 24 and 48 hours after admission. |
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