Cardiovascular Effects of Aerosols in Residences Study

Status Completed

Clinical Trial Summary

This study is focused on the effects of HEPA filtration to reduce exposures to combustion-derived air pollution (CDAP). Specifically, the study will evaluate the health benefits of HEPA filters and compare the cardiovascular toxicity of two major sources of CDAP, specifically traffic and residential wood combustion.

Specifically, the purpose of this study is to evaluate the ability of portable high efficiency particle air (HEPA) filters to reduce exposures to PM2.5 and air pollution indoors and to improve subclinical indicators of microvascular function and systemic inflammation among healthy adult participants.

The investigators hypothesize that HEPA filter use will help decrease indoor concentrations of CDAP thereby helping to mitigate the associated cardiovascular risks.

Clinical Trial Description

To address knowledge gaps about health risks of specific pollution sources and to provide new evidence on the health benefits of air pollution interventions, the objectives of this study are: 1) quantify the relationship between low-level exposures to combustion-derived PM air pollution and subclinical indicators of cardiovascular disease risk; and 2) compare the relative impact of HEPA filtration for two major PM sources (traffic and residential wood combustion) on these indicators.

The use of HEPA filters may help to mitigate cardiovascular risks factors caused by combustion-derived air pollution (CDAP), (specifically woodstove and traffic emissions). We hypothesize that HEPA filter use and improved woodstove technology will help decrease indoor occurrences of CDAP. This project will help address knowledge gaps in CDAP-related health risks and benefits of interventions. Specific objectives include establishing a relationship between exposure to CDAP and biomarkers of cardiovascular risk and evaluating the impact of HEPA filter use towards improved indoor air quality and health indicators. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01570062
Study type	Interventional
Source	Simon Fraser University
Contact
Status	Completed
Phase	Phase 2
Start date	November 2011
Completion date	August 2012

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02122198` - Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women	N/A
Completed	`NCT04156711` - Remote Ischemic Preconditioning in Patients Undergoing Acute Minor Abdominal Surgery	N/A
Recruiting	`NCT06133634` - Fisetin to Improve Vascular Function in Older Adults	Phase 1/Phase 2
Completed	`NCT05872139` - Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging	N/A
Recruiting	`NCT04558450` - Covid-19 Effects on Arterial Stiffness and Vascular Aging (CARTESIAN)	N/A
Terminated	`NCT03325933` - Resistance Training and Cardiometabolic Health	N/A
Not yet recruiting	`NCT05939934` - Impact of the Mandibular Advancement Device on Sleep Apnea During CPAP Withdrawal	N/A
Completed	`NCT02652975` - Anticancer Treatment of Breast Cancer Related to Cardiotoxicity and Dysfunctional Endothelium	N/A
Recruiting	`NCT02334839` - The Association Between Severity of Hypertensive Disorder During Pregnancy and Endothelial Dysfunction	N/A
Recruiting	`NCT02020044` - Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)	N/A
Completed	`NCT01691404` - Study on the Effects of Epicatechin and Quercetin Supplementation on Vascular Function and Blood Pressure (FLAVO)	N/A
Completed	`NCT01775865` - Targeting Inflammation to Treat Cardiovascular Aging	Phase 2
Terminated	`NCT01412216` - The Effects of Sedentarism on Vascular Function, Inflammation, and Insulin Resistance	Phase 2
Completed	`NCT01319344` - Effect of Eplerenone on Endothelial Function in Metabolic Syndrome	Phase 3
Completed	`NCT00848302` - Endothelial Function in Human Arteries	Early Phase 1
Completed	`NCT00990730` - Atherosclerosis in Rheumatoid Arthritis	N/A
Completed	`NCT00987974` - Short Term Statin Treatment and Endothelial Dysfunction Due to Ischemia and Reperfusion Injury	Phase 4
Completed	`NCT00532844` - A Phase 2, Pharmacokinetic (PK) Study of 6R-BH4 Alone or 6R-BH4 With Vitamin C in Subjects With Endothelial Dysfunction	Phase 2
Completed	`NCT00376246` - Effect of Ezetimibe on Flow-mediated Brachial Artery Reactivity in Healthy Subjects	Phase 4
Completed	`NCT00775099` - Combustion Derived Air Pollution and Vascular Function	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Cardiovascular Effects of Aerosols in Residences Study — CLEAR

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms