Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Changes in endothelial function measured by reactive hyperemia index (RHI) |
Changes in endothelial function measured by reactive hyperemia index (RHI) at baseline, four hours and 24 hours after surgery (cholecystectomy due to acute cholecystitis) |
24 hours |
|
Secondary |
Heart rate variability |
Changes in Heart rate variability measured with eMotion Faros from baseline and 24 hours consecutively. |
24 hours |
|
Secondary |
Changes in p-L-arginine |
Changes in p-L-arginine in µmol/L from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in p-asymmetric dimethylarginine |
Changes in p-asymmetric dimethylarginine in µmol/L from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in p-biopterins |
Changes in p-biopterins in ng/ml from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in soluble endothelial (E-) selectin |
Changes in soluble E-selectin in ng/ml from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in soluble plasma (P-) selectin |
Changes in soluble P-selectin in ng/ml from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in Intercellular Adhesion Molecule 1 (ICAM-1) |
Changes in soluble Intercellular Adhesion Molecule 1 (ICAM-1) in ng/ml from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in syndecan-1 |
Changes in syndecan-1 in pg/ml from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in thrombomodulin |
Changes in thrombomodulin in pg/ml from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in arginine vasopressin |
Changes in arginine vasopressin in ng/ml from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in adrenalin |
Changes in adrenalin in ng/ml from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in noradrenalin |
Changes in noradrenalin in pg/ml from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in ascorbic acid |
Changes in ascorbic acid in ng/µL from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in dehydroascorbic acid |
Changes in dehydroascorbic acid in ng/µL from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in angiotensin II |
Changes in angiotensin II in pg/mL from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in bradykinin |
Changes in bradykinin in pg/mL from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in calcitonin-gene related peptide |
Changes in calcitonin-gene related peptide in pg/mL from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in prostacyclin |
Changes in prostacyclin in pg/mL from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in serotonin |
Changes in serotonin in ng/mL from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in endothelin-1 |
Changes in endothelin-1 in pg/mL from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in adrenomedullin |
Changes in adrenomedullin in ng/mL from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in platelets |
Changes in platelets x 109/L from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in adenosin |
Changes in adenosin µmol/L from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in interleukin-6(IL-6), interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta) |
Changes in IL-6, IL-10, TNF-Alpha, TGF-beta in pg/mL from baseline til 24h post-surgery |
24 hours |
|
Secondary |
Changes in gene expression autoimmune human pathway panel from NanoString |
Changes in gene expression profiles in the autoimmune human pathway panel from NanoString from baseline until four hours post-surgery. |
4 hours |
|
Secondary |
Local complications to RIPC |
Pain, changed sensibility or decreased function of the upper extremity where remote ischemic preconditioning were carried out preoperatively. |
24 hours |
|
Secondary |
Differences in postoperative quality of recovery score 15 (QoR-15) between arms in the trial |
Questionnaire on Postoperative quality of recovery with 15 questions comparing scores from baseline, 24 hours and 30 days after surgery between study arms (intervention and controls) |
30 days |
|
Secondary |
Differences in Self reported pain on a 0-10 scale between arms in the trial |
Self reported pain on a 0-10 scale at baseline and 24 hours after surgery between study arms (intervention and controls) |
24 hours |
|