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Propofol and Magnesium Sulfate Intravenous Infusion During Endoscopic Sinus Surgery

Endoscopic Sinus Surgery Clinical Trial

Official title:
Controlled Hypotension During Endoscopic Sinus Surgery: A Comparison of Propofol and Magnesium Sulfate

Clinical Trial Summary

Endoscopic Sinus surgery usually associated by bleeding, despite using of local vasopressor injection, head up position- controlled hypotension is generally used for control of this purpose.

Propofol has been reported as a good agent for controlled hypotension by decreasing systemic vascular resistance secondary to arterial and venous vasodilation and a decrease in myocardial contractility with a dose-dependent property.

Magnesium Sulfate also has been reported as an agent of hypotensive anaesthesia by inhibition of the release of norepinephrine by blocking N-type calcium channel at the nerve ending beside acting as a vasodilator.

The well known pharmacodynamic effects of the intravenous infusion of propofol or Magnesium Sulfate may prove the advantage of this group in controlling intraoperative blood pressure thus reducing surgical field bleeding.

Clinical Trial Description

The aim of the work to compare the efficacy of propofol and magnesium sulfate to control blood pressure during endoscopic sinus surgery and the resultant effects on the quality of the surgical field including bleeding and visibility. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04078659
Study type Interventional
Source Mansoura University
Contact Nabil A Abd El-Mageed, MD
Phone 00201001538648
Email nabil-abdelraouf@yahoo.com
Status Not yet recruiting
Phase N/A
Start date September 2019
Completion date February 2020
View Details
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