Endometriosis Clinical Trial
Official title:
Efficacy of Postoperative Cyclic Oral Contraceptive Use After Gonadotropin-releasing Hormone Agonist for the Prevention of Endometrioma Recurrence
Ovarian endometriotic cyst (endometrioma) is one of the most common endometriotic lesions,
and conservative laparoscopic surgery is the treatment of choice. However, the recurrence
after surgery is common.
As repetitive surgery leads to morbidities and ovarian function decrease, recurrence after
surgery frustrates both patients and clinicians. In this aspect, medical treatments have
been offered after surgery to prevent or delay the recurrence. Gonadotropin-releasing
hormone agonist (GnRHa) is frequently used in women with advanced endometriosis, but the
efficacy is rather controversial. On the other hand, it has been demonstrated that oral
contraceptives (OCs) could reduce or delay endometrioma recurrence, but data are still
limited. Consequently, no one type of postoperative medical therapy has been shown to be
superior in reducing the recurrence of endometrioma.
The rationale of postoperative medical therapy is that it could eradicate microscopic
lesions which were not found and not treated sufficiently during surgery. Therefore, the
maintenance of strongly suppressed condition induced by postoperative GnRHa treatment by
addition of OCs could be a promising treatment to prevent the recurrence, but it has not
been widely investigated.
We performed this retrospective cohort study to evaluate the efficacy of cyclic monophasic
low-dose OCs as a maintenance therapy after GnRHa treatment for the suppression of
endometrioma recurrence.
n/a
Observational Model: Cohort, Time Perspective: Retrospective
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