Endometriosis Clinical Trial
Official title:
Pretreatment With Dienogest in Women With Endometriosis Undergoing in Vitro-fertilization After a Previous Failed Cycle
It is generally assumed that the major causes of in vitro fertilization (IVF) failure in women with endometriosis are diminished ovarian reserve, impaired endometrial receptivity and low quality of embryos. The use of prolonged courses of hormone therapy may play an important role in the strategy of overcoming endometriosis-related infertility. The aim of this study was to evaluate the use of dienogest (DNG) before an IVF cycle in women with endometriosis undergone a previous IVF failed cycle
The primary outcomes of the study are clinical pregnancy rate and live birth rate after
reaching 24 week's gestation.
Secondary outcomes of the study are: changes in the diameter and volume of the largest
endometrioma, total gonadotropin dose administered, number of mature oocytes collected,
number of two-pronuclear (2PN) embryos, number of blastocysts.
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