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Endometriosis clinical trials

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NCT ID: NCT06421857 Completed - Endometrioma Clinical Trials

Hemostatic Measures During Laparoscopic Cystectomy for Endometrioma

Start date: September 1, 2023
Phase: N/A
Study type: Interventional

laparoscopic excision of ovarian endometriotic cysts is generally recommended because it has been associated with a higher spontaneous conception rate, residual ovarian function after the procedure may be affected

NCT ID: NCT06356753 Completed - Endometriosis Clinical Trials

EndoxOmics : Exposome, Endometriosis and Fertility

EndoxOmics
Start date: September 1, 2019
Phase:
Study type: Observational

For several years, the effects of environmental pollution on human health have been a growing concern for the scientific community and public authorities. Among the many known chemical contaminants, persistent organic pollutants (POPs) are of particular concern because of their properties as endocrine disrupters, bioaccumulation and biomagnification. The associations between environmental pollutants, endometriosis and infertility remains poorly understood. The objective of this exploratory non interventional monocentric study conducted in the University Hospital of Nantes, is to identify endogenous molecular profiles associated with endometriosis and related infertility. This project implements an exploratory approach combining exposure and metabolomics approaches based on high-resolution mass spectrometry to identify exposure and metabolomics profiles associated with infertility, and biomarkers for potential prognostic application.

NCT ID: NCT06298617 Completed - Endometriosis Clinical Trials

Systemic Inflammatory Indices as a Non-invasive Grading Modality for Endometriosis

Start date: January 1, 2023
Phase:
Study type: Observational

Endometriosis (EMs) is one of the commonest chronic inflammatory disorder affecting women and is characterized by the presence and growth of endometrial-like glandular epithelial and stromal cells outside the uterus leading to multiple clinical symptoms affecting patients quality of life and fertility with high recurrence rate . The systemic immune inflammatory index (SII) and systemic inflammatory response index (SIRI) are documented as prognostic serum biomarker in many kinds of cancer and for the need and outcomes of adjuvant therapies for various cancers .

NCT ID: NCT06274086 Completed - Endometrioma Clinical Trials

Two-session Catheter-directed Sclerotherapy Using Ethanol for Endometrioma

Start date: June 1, 2020
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to evaluate the safety and clinical outcomes of two-session catheter-directed sclerotherapy (CDS) with 96% ethanol in patients with endometrioma. The main question it aims to answer is: • Is two-session CDS with 96% ethanol safe and effective for treating endometrioma? Participants will: - Receive the first session CDS for endometrioma - Carry the catheter overnight and be monitored in the patient ward - Receive the second session CDS the next day

NCT ID: NCT06241040 Completed - Endometriosis Clinical Trials

Effects of Aerobic Exercise and Core Muscle Strengthening on Pain, Menstrual Pattern and QOL in Endometriosis

Start date: March 15, 2023
Phase: N/A
Study type: Interventional

Endometriosis is a complex and debilitating gynecological condition affecting millions of women worldwide. It is characterized by the abnormal growth of endometrial-like tissue outside the uterus, leading to chronic pelvic pain, dysmenorrhea, dyspareunia, and reduced quality of life. While pharmacological interventions are commonly prescribed to manage symptoms, their efficacy may be limited, and they often come with adverse effects. Therefore, exploring non-pharmacological approaches, such as exercise, is crucial in improving the management of endometriosis-related symptoms. Aerobic exercise has gained attention as a potential therapeutic intervention for endometriosis due to its positive effects on pain modulation, hormonal regulation, and overall well-being.

NCT ID: NCT06219044 Completed - Endometrioma Clinical Trials

Evaluation of Ovarian Reserve and Recurrence Rate After DWLS Diode Laser OMA Vaporization

OMAlaser
Start date: March 1, 2021
Phase: N/A
Study type: Interventional

PURPOSE OF THE STUDY The study aims to evaluate the effectiveness of the Dual Wavelength Laser System (DWLS) diode laser on the treatment of endometrioma (OMA), with ablation and vaporization of the cystic capsule without performing the stripping technique, in terms of ovarian reserve and recurrence rate.

NCT ID: NCT06207448 Completed - Endometriosis Ovary Clinical Trials

Deep Infiltrating Endometriosis : Laparoscopic Nerve-sparing Surgery and Use of Neutral Argon Plasma

DIE
Start date: April 1, 2022
Phase:
Study type: Observational

Medical treatment of endometriosis has a suspensive and sometimes incomplete effect on the symptoms, making surgical treatment necessary. The aim of surgical treatment of deep endometriosis is to restore normal anatomy and functional integrity. Resection of deep endometriosis lesions is recommended to relieve pain, gynecological and digestive symptoms, but rarely urinary disorders. Nerve-sparing surgery, when feasible, reduces post-operative dysuria by sparing the lower hypogastric plexus. The major limitations of these surgical procedures are the experience of the surgeon and the extent of the disease. Acquiring the surgical techniques and skills necessary to carry out these types of procedures is essential to providing optimal patient care.

NCT ID: NCT06187558 Completed - Endometriosis Clinical Trials

Suspension of the Pelvic and Abdominal Organs During Minimally Invasive Surgery

Start date: March 1, 2019
Phase:
Study type: Observational

The goal of this retrospective observational study is to evaluate the efficacy, safety, and practicality of an organ suspension technique with adjustable tension suture in facilitating minimally invasive gynecologic surgeries at the University Hospital of Cagliari, Italy. The main questions it aims to answer are: - Is the organ suspension technique using adjustable tension suture both cost-effective and practical for minimally invasive gynecologic surgeries? - How safe, effective, and feasible is this suspension technique when applied to patients with benign or malignant gynecological diseases undergoing laparoscopic surgery? Participants in this study underwent laparoscopic surgery involving the organ suspension technique, which includes: - The use of a modified Foley catheter and Polyglactin suture for organ suspension. - The collection of preoperative and postoperative data, such as operation times, blood loss, hospital stay duration, and short-term postoperative complications. This study does not include a comparison group, focusing instead on the direct outcomes and experiences of the participants who underwent the specified surgical technique.

NCT ID: NCT06106932 Completed - Endometriosis Clinical Trials

GnRH-a on Angiogenesis of Endometriosis

Start date: September 2015
Phase: N/A
Study type: Interventional

Purpose: Neo-angiogenesis is necessary for adhesion and invasiveness of endometriotic lesions in women affected by endometriosis. VEGF is one of the major components of angiogenesis and is part of the major pathway TF-PAR-2-VEGF that leads to neo-angiogenesis. SP1 is a transcriptional factor that has lately been studied for its crucial role in angiogenesis, via a distinct pathway. We hypothesize that by blocking angiogenetic pathways we can repress endometriotic lesions. GnRH-agonists are routinely used, especially pre-operatively, in endometriosis. It would be interesting to clarify which angiogenetic pathways are affected and pave the way for further research over anti-angiogenetic effects on endometriosis. Methods: We used qRT-PCR to study mRNA expression levels of TF, PAR-2, VEGF and SP1 in endometriotic tissues of women who underwent surgery for endometriosis and received GnRH-a [leuprolide acetate] preoperatively.

NCT ID: NCT05868057 Completed - Clinical trials for Endometriosis, Uterine Fibroids, Male Hormone-sensitive Prostate Cancer, Assisted Reproduction

A Clinical Study Evaluating the Relative Bioavailability of SHR7280 Dry Suspension and Tablets

Start date: May 23, 2023
Phase: Phase 1
Study type: Interventional

To assess the relative bioavailability of SHR7280 dry suspension and tablets in healthy subjects. To assess the safety and tolerability of a single dose of SHR7280 dry suspension and tablets.